caa a22 4500 475747712 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810000022 doi (NATIONALLICENCE)springer-10.1007/s002810000022 Weiner George Interdisciplinary Graduate Program in Immunology, University of Iowa Cancer Center, Department of Internal Medicine, 200 Hawkins Drive, 5970 JPP, 52242, Iowa City, IA, USA aut Immunostimulatory DNA sequences and cancer therapy [Elektronische Daten] [George Weiner] Conclusions: The relationship between the immune system and malignancy is extremely complex. Recent advances in our understanding of this interaction, and the success of select monoclonal antibody treatments of cancer, have reawakened interest in the field of cancer immunotherapy. Recent recognition of the potent immunostimulatory effects of select sequences of DNA suggest that such agents may well be important if cancer immunotherapy is to play a major role in our treatment and prevention of malignancy. Preliminary studies suggest these sequences can be effective, alone or in combination with antibodies, at inducing tumor regression. Perhaps even more promising is their ability to enhance development of an antigen-specific antitumor response when used as a vaccine adjuvant, as an agent capable of stimulating APCs or as part of DNA immunization strategy. Further work with Immunostimulatory DNA in both the laboratory and the clinic is needed before we can know their true promise in cancer therapy. Springer-Verlag, 2000 Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 107-116 0344-4325 22:1-2<107 2000 22 281 https://doi.org/10.1007/s002810000022 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000022 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Weiner George Interdisciplinary Graduate Program in Immunology, University of Iowa Cancer Center, Department of Internal Medicine, 200 Hawkins Drive, 5970 JPP, 52242, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 107-116 0344-4325 22:1-2<107 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer