caa a22 4500 47574778X CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810000019 doi (NATIONALLICENCE)springer-10.1007/s002810000019 The discovery of immunostimulatory DNA sequence [Elektronische Daten] [Saburo Yamamoto, Toshiko Yamamoto, Tohru Tokunaga] Conclusions: The concept of immunostimulatory DNA sequence was born in a long series of studies on BCG-mediated tumor resistance. DNA purified from BCG inhibited the growth of various animal tumors, augmented cell activity and induced IFN from mouse spleen cells. Further, we found two remarkable facts (1) DNA from bacteria, but not animals and plants, showed the above-mentioned immunogical activity, and (2) the activity was completely dependent on particular base sequences having CpG motifs. Research interests of immunostimulatory DNA sequences were galvanized in 1995 by the report of Krieg showing murine B cell activation with bacterial DNA containing CpG motifs [9]. Within a short period of time, a huge number of papers have been published in this field, and the study has expanded rapidly and widely. Now, it includes a number of research fields, for example, host-defense mechanisms against infection, allergy, autoimmune diseases, cytokine networks, plasmid vaccination, and therapeutic application of certain diseases [5, 8, 11, 15, 16, 29]. The response of higher animals against immunostimulatory DNA must be the most primitive but important mechanism for self-nonself discrimination against foreign DNA. Springer-Verlag, 2000 Yamamoto Saburo Department of Bacterial and Blood Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, 208-0011, Tokyo, Japan aut Yamamoto Toshiko Department of Bacterial and Blood Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, 208-0011, Tokyo, Japan aut Tokunaga Tohru Fukuoka Jo-Gakuin University, Fukuoka, Japan aut Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 11-19 0344-4325 22:1-2<11 2000 22 281 https://doi.org/10.1007/s002810000019 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000019 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamamoto Saburo Department of Bacterial and Blood Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, 208-0011, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto Toshiko Department of Bacterial and Blood Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, 208-0011, Tokyo, Japan aut NATIONALLICENCE 700 1- Tokunaga Tohru Fukuoka Jo-Gakuin University, Fukuoka, Japan aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 11-19 0344-4325 22:1-2<11 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer