caa a22 4500 475747798 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810000021 doi (NATIONALLICENCE)springer-10.1007/s002810000021 Pisetsky David Division of Rheumatology, Allergy and Clinical Immunology, Durham VA Medical Center and Duke University Medical Center, Room E-1008, 508 Fulton Street, Box 15IG, 27705, Durham, NC, USA aut Mechanisms of immune stimulation by bacterial DNA [Elektronische Daten] [David Pisetsky] Conclusion: Bacterial DNA promotes powerful immune system activation because of its content of characteristic sequence motifs. These sequences induce cellular changes that promote inflammation and the generation of Thl responses. This activation involves internalization of DNA as well as the activation of NF-κB and stress kinases. Future studies will identify DNA-binding molecules that are key to these activation events and may serve as targets for novel immunomodulatory agents. Springer-Verlag, 2000 Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 21-33 0344-4325 22:1-2<21 2000 22 281 https://doi.org/10.1007/s002810000021 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000021 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pisetsky David Division of Rheumatology, Allergy and Clinical Immunology, Durham VA Medical Center and Duke University Medical Center, Room E-1008, 508 Fulton Street, Box 15IG, 27705, Durham, NC, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 21-33 0344-4325 22:1-2<21 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer