caa a22 4500 47574781X CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810050019 doi (NATIONALLICENCE)springer-10.1007/s002810050019 Krieg Arthur Department of Veterans Affairs Medical Center, 52246, Iowa City, IA, USA aut Signal transduction induced by immunostimulatory CpG DNA [Elektronische Daten] [Arthur Krieg] The immune recognition of unmethylated CpG motifs appears to be an example of the ability of the immune system to detect molecular patterns which are characteristic of microbes, but are not present in vertebrates. This detection is accomplished by the means of pattern recognition receptors (PRR). Unlike some other examples of PRR, immune recognition of CpG DNA appears to require cell uptake and to be accomplished through an intracellular PRR system. This then results in the activation of mitogen-activated protein kinases, culminating in the phosphorylation of transcription factors and the activation of transcription and translation. The rapid activation of these pathways by CpG DNA leads to the induction of protective immune responses. Springer-Verlag, 2000 Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 97-105 0344-4325 22:1-2<97 2000 22 281 https://doi.org/10.1007/s002810050019 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810050019 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Krieg Arthur Department of Veterans Affairs Medical Center, 52246, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 97-105 0344-4325 22:1-2<97 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer