caa a22 4500 475747828 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810000017 doi (NATIONALLICENCE)springer-10.1007/s002810000017 The response of human B lymphocytes to oligodeoxynucleotides [Elektronische Daten] [Hua Liang, Peter Lipsky] Conclusios: ISS induce T cell-independent polyclonal activation of human B cell by engaging surface Ig. Manifestations of ISS-induced human B cell activation include expression of activation markers, proliferation, and Ig production as well as anti-DNA antibody production. IL-2, IL-6 and intact T cells enhanced B cell responses to ISS, but were not required for B cell activation. Human monocytes enhanced B cell responses induced by ISS, particularly Ig secretion. The chemical nature of sODNs capable of stimulating human B cells has not been completely delineated. Further studies will be necessary and important for developing novel therapeutic and preventive agents in humans using ISS. Springer-Verlag, 2000 Liang Hua Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 75235-8884, Dallas, TX, USA aut Lipsky Peter Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 75235-8884, Dallas, TX, USA aut Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 63-75 0344-4325 22:1-2<63 2000 22 281 https://doi.org/10.1007/s002810000017 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liang Hua Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 75235-8884, Dallas, TX, USA aut NATIONALLICENCE 700 1- Lipsky Peter Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 75235-8884, Dallas, TX, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 63-75 0344-4325 22:1-2<63 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer