caa a22 4500 475747852 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002810000024 doi (NATIONALLICENCE)springer-10.1007/s002810000024 Pisetsky David Division of Rheumatology, Allergy and Clinical Imunology, Durham VA Medical Center and Duke University Medical Center, Room E-1008, 508 Fulton Street, Box 151G, 27705, Durham, NC, USA aut The antigenic properties of bacterial DNA in normal and aberrant immunity [Elektronische Daten] [David Pisetsky] Conclusions: DNA is a complex macromolecule whose immunological properties result from structural microheterogeneity. In normal immunity, antibodies to DNA can arise by stimulation by bacterial DNA because of the adjuvant properties of foreign DNA as well as the presence of non-conserved sequences that serve as B cell epitopes. In SLE, anti-DNA antibodies arise by a process of DNA antigen drive and could result from stimulation by either self or foreign DNA. Since foreign DNA is immunogenic, this antigen may have an enhanced ability to drive anti-DNA autoantibody production in the individual with functional abnormalities in the B or T cell compartment. Future research will define further the interaction of foreign DNA with the normal as well aberrant immune system and hopefully lead to strategies to eliminate the production of pathogenic anti-DNA autoantibodies. Springer-Verlag, 2000 Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 153-166 0344-4325 22:1-2<153 2000 22 281 https://doi.org/10.1007/s002810000024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002810000024 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pisetsky David Division of Rheumatology, Allergy and Clinical Imunology, Durham VA Medical Center and Duke University Medical Center, Room E-1008, 508 Fulton Street, Box 151G, 27705, Durham, NC, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 22/1-2(2000-03-01), 153-166 0344-4325 22:1-2<153 2000 22 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer