caa a22 4500 47574795X CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/BF00870302 doi (NATIONALLICENCE)springer-10.1007/BF00870302 Alterations in the regulation of expression of the αl(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma) [Elektronische Daten] [Sergio Jimenez, Biagio Saitta] Summary: At present, the mechanisms that regulate the expression of collagen genes in normal and pathologic fibroblasts are not known. Thus, the detailed study of transcriptional regulation of COL1A1 in SSc cells will increase our current understanding of the pathophysiology of fibrotic diseases. These studies will yield valuable information regarding the important biological process of regulation of collagen gene expression under normal and pathologic conditions, a process that has remained elusive despite intense recent investigations. It is now evident that persistent overproduction of collagen is responsible for the progressive nature of tissue fibrosis in SSc. Up-regulation of collagen gene expression in SSc fibroblasts appears to be a critical event in this process. The coordinate transcriptional activation of numerous collagen genes suggests a fundamental alteration in the regulatory control of gene expression in SSc fibroblasts. Trans-acting nuclear factors which bind to cis-acting elements in enhancer (intronic) and promoter regions of the genes modulate the basal and inducible transcriptional activity of the collagen genes. The identification of the nuclear transcription factors that regulate normal collagen gene expression may provide promising approaches to the therapy of this incurable disease. Springer-Verlag, 2000 Jimenez Sergio Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 S. 10th Street, Room 509 BLSB, 19107-5541, Philadelphia, PA, USA aut Saitta Biagio Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 S. 10th Street, Room 509 BLSB, 19107-5541, Philadelphia, PA, USA aut Springer Seminars in Immunopathology Springer-Verlag 21/4(2000-06-01), 397-414 0344-4325 21:4<397 2000 21 281 https://doi.org/10.1007/BF00870302 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00870302 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jimenez Sergio Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 S. 10th Street, Room 509 BLSB, 19107-5541, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Saitta Biagio Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 S. 10th Street, Room 509 BLSB, 19107-5541, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Springer Seminars in Immunopathology Springer-Verlag 21/4(2000-06-01), 397-414 0344-4325 21:4<397 2000 21 281 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer