caa a22 4500 475747976 CHVBK 20180406123518.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006646711977 doi (NATIONALLICENCE)springer-10.1023/A:1006646711977 Lymphoproliferative Responses to Mitogens and Prepared Antigens of M. avium Complex in Patients with HIV Infection [Elektronische Daten] [Richard Novak, Janak Koirala, Mohammad Sirdar, Nausica D'alfonso-Laghi, Luiz Moreira, David Pitrak, Mahmood Ghassemi] Published reports have demonstrated that antigens of Mycobacterium avium complex (MAC) can suppress the normal response to mitogens in lymphoproliferation assays. We therefore studied the lymphoproliferative (LP) function of PBMC from 55 HIV-infected patients and 16 controls in response to mitogens with and without MAC antigen. As expected, LP responses decline with progressive decline in CD4 count; MAC antigen in combination with PHA further suppresses that response in a dose-dependent manner. More relevant were the LP responses in those with CD4 counts less than 100. All patients with MAC disease had poor responses (stimulation index, SI < 10) to PHA or anti-CD3 with or without MAC antigen. Those who did not have nor subsequently developed MAC were both good (SI > 10) or poor responders (SI < 10). The suppressive effect of MAC on lymphocyte function may serve as a weak virulence factor which is only relevant in severely immunocompromised HIV patients. Plenum Publishing Corporation, 2000 HIV nationallicence mycobacteria nationallicence lymphocyte nationallicence M. avium nationallicence activation nationallicence Novak Richard University of Illinois, Chicago, Illinois, USA aut Koirala Janak University of Illinois, Chicago, Illinois, USA aut Sirdar Mohammad University of Illinois, Chicago, Illinois, USA aut D'alfonso-Laghi Nausica University of Illinois, Chicago, Illinois, USA aut Moreira Luiz University of Illinois, Chicago, Illinois, USA aut Pitrak David University of Illinois, Chicago, Illinois, USA aut Ghassemi Mahmood University of Illinois, Chicago, Illinois, USA aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 62-67 0271-9142 20:1<62 2000 20 10875 https://doi.org/10.1023/A:1006646711977 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006646711977 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Novak Richard University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Koirala Janak University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Sirdar Mohammad University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- D'alfonso-Laghi Nausica University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Moreira Luiz University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Pitrak David University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Ghassemi Mahmood University of Illinois, Chicago, Illinois, USA aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 62-67 0271-9142 20:1<62 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer