caa a22 4500 475747984 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006682225181 doi (NATIONALLICENCE)springer-10.1023/A:1006682225181 van Bekkum Dirk Introgene BV, PO Box 2048, 2301 CA, The Netherlands aut Stem Cell Transplantation in Experimental Models of Autoimmune Disease [Elektronische Daten] [Dirk van Bekkum] A review of the experiments with animal models of autoimmune disease (AID) that have provided the rationale for the present clinical investigations on the use of autologous stem cells for treating patients with severe refractory AID. The various types of AID in laboratory animals and the recognition of the key-role of hematopoitic stem cells (HSC) in AID are discussed. Two animal models were employed for translational research on autologous bone marrow transplantation (BMT): adjuvant arthritis (AA) as model for rheumatoid arthritis (RA) and experimental allergic encephalomyelitis (EAE) as model for multiple sclerosis (MS). The principal aspects of the treatment, i.e., conditioning agents and doses and T cell depletion of the autograft, were investigated in relation to remission induction and the incidence of relapses. Plenum Publishing Corporation, 2000 Autoimmune disease nationallicence hematopoietic stem cells nationallicence autologous transplant nationallicence Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 10-16 0271-9142 20:1<10 2000 20 10875 https://doi.org/10.1023/A:1006682225181 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006682225181 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- van Bekkum Dirk Introgene BV, PO Box 2048, 2301 CA, The Netherlands aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 10-16 0271-9142 20:1<10 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer