caa a22 4500 475748026 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006650812886 doi (NATIONALLICENCE)springer-10.1023/A:1006650812886 IgG Anti-IgA Subclasses in Common Variable Immunodeficiency and Association with Severe Adverse Reactions to Intravenous Immunoglobulin Therapy [Elektronische Daten] [Maria Sato, Alberto da Silva Duarte] The current therapy for common variable immunodeficiency is based on the administration of intravenous immunoglobulin preparations which may cause severe adverse reactions. Some reports have associated these reactions with IgG anti-IgA antibodies, although this is not yet clear. We analyzed 20 sera from common variable immunodeficiency patients by an enzyme immunoassay to detect IgG anti-IgA and determine its subclass profile. Five patients presented high levels of these antibodies, all of them had IgG1, two had IgG2 and IgG4 and one had IgG3. Three of these five patients were receiving non IgA depleted intravenous immunoglobulin and had no severe adverse reactions. One patient had persisted with similar high levels of IgG anti-IgA during three years. Therefore, the IgG anti-IgA antibodies, regardless to their subclass profile in the common variable immunodeficiency patients sera do not seem to be associated with severe adverse reactions to intravenous immunoglobulins. Plenum Publishing Corporation, 2000 Common variable immunodeficiency nationallicence intravenous immunoglobulin nationallicence severe adverse reactions nationallicence IgG anti-IgA subclasses nationallicence Sato Maria Laborat´orio de Alergia e Imunologia Cl´ınica e Experimental (LIM-56), Faculdade de Medicina, da Universidade de S~ao Paulo, S~ao Paulo, Brasil aut da Silva Duarte Alberto Laborat´orio de Alergia e Imunologia Cl´ınica e Experimental (LIM-56), Faculdade de Medicina, da Universidade de S~ao Paulo, S~ao Paulo, Brasil aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 77-82 0271-9142 20:1<77 2000 20 10875 https://doi.org/10.1023/A:1006650812886 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006650812886 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Maria Laborat´orio de Alergia e Imunologia Cl´ınica e Experimental (LIM-56), Faculdade de Medicina, da Universidade de S~ao Paulo, S~ao Paulo, Brasil aut NATIONALLICENCE 700 1- da Silva Duarte Alberto Laborat´orio de Alergia e Imunologia Cl´ınica e Experimental (LIM-56), Faculdade de Medicina, da Universidade de S~ao Paulo, S~ao Paulo, Brasil aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 77-82 0271-9142 20:1<77 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer