caa a22 4500 475748034 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006642611069 doi (NATIONALLICENCE)springer-10.1023/A:1006642611069 Phagocytic Killing and Antibody Response During the First Year After Tetravalent Meningococcal Vaccine in Complement-Deficient and in Normal Individuals [Elektronische Daten] [Menache Schlesinger, Helena Kayhty, Rachel Levy, Chaim Bibi, Naftaly Meydan, Jacov Levy] Seven individuals with late complement component (LCC) deficiency and seven control subjects were vaccinated with tetravalent meningococcal vaccine. The response to vaccination was evaluated by measuring the antibody titer and the phagocyte killing of the bacteria, before, 5-7 weeks, and 12-14 months after vaccination. Prior to vaccination, no phagocytic killing and a low titer of antibody was found in the LCC-deficient group and a low killing (mean of 40-58%, according to the serogroup) in normal controls. The phagocytic killing increased significantly 5-7 weeks after vaccination. However, while in normal controls the phagocytic killing was close to 100% after 5-7 weeks and decreased only slightly during the first year, the mean killing of the various meningococcal subgroups in LCC-deficient individuals was 70-89% and dropped to only 53-71% one year after vaccination. Six weeks after vaccination the mean antimeningococcal antibody titer increased similarly in the sera of LCC-deficient patients and controls. One year after vaccination the controls maintained the high concentration, while the LCC-deficient patients had tendency toward a decrease. In addition, the interpersonal variability of the antibody concentration, both in LCC-deficient individuals and in normal controls, was much higher than the phagocytic killing, with only a very mild increase in some individuals. Thus, it is possible that in spite of adequate increase of antimeningococcal antibody titer after vaccination of LCC-deficient individuals their immunity against the bacteria may not be optimal. Our data show also that phagocytic killing of meningococci is probably a more consistent assay than antibody titer levels for antimeningococcal immunity, especially in LCC-deficient patients. Plenum Publishing Corporation, 2000 Meningococcus nationallicence vaccination nationallicence complement deficiency nationallicence Schlesinger Menache Department of Pediatrics and Immunology, Barzilai Medical Centre, 78306, Ashkelon, Israel aut Kayhty Helena National Public Health Institute, Helsinki, Findland aut Levy Rachel Laboratory of Infectious Disease, Clinical Biochemistry Unit, Faculty of Health Sciences, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel aut Bibi Chaim Department of Pediatrics and Immunology, Barzilai Medical Centre, 78306, Ashkelon, Israel aut Meydan Naftaly Department of Pediatrics, Ben Gurion University of the Negev, Beer Sheva, Israel aut Levy Jacov Department of Pediatrics, Ben Gurion University of the Negev, Beer Sheva, Israel aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 46-53 0271-9142 20:1<46 2000 20 10875 https://doi.org/10.1023/A:1006642611069 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006642611069 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlesinger Menache Department of Pediatrics and Immunology, Barzilai Medical Centre, 78306, Ashkelon, Israel aut NATIONALLICENCE 700 1- Kayhty Helena National Public Health Institute, Helsinki, Findland aut NATIONALLICENCE 700 1- Levy Rachel Laboratory of Infectious Disease, Clinical Biochemistry Unit, Faculty of Health Sciences, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel aut NATIONALLICENCE 700 1- Bibi Chaim Department of Pediatrics and Immunology, Barzilai Medical Centre, 78306, Ashkelon, Israel aut NATIONALLICENCE 700 1- Meydan Naftaly Department of Pediatrics, Ben Gurion University of the Negev, Beer Sheva, Israel aut NATIONALLICENCE 700 1- Levy Jacov Department of Pediatrics, Ben Gurion University of the Negev, Beer Sheva, Israel aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 46-53 0271-9142 20:1<46 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer