caa a22 4500 475748042 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006638510160 doi (NATIONALLICENCE)springer-10.1023/A:1006638510160 Intense Immune Suppression for Systemic Lupus—The Role of Hematopoietic Stem Cells [Elektronische Daten] [Richard Burt, Alberto Marmont, James Schroeder, Robert Rosa, Ann Traynor] The treatment of severe autoimmune diseases has been recently revitalized by the introduction of intense immune suppression with immune ablative intent followed by three different procedures. These are allogeneic hematopoietic stem cell transplantation (HSCT), autologous HSCT (using either marrow or peripheral blood), and intense immune suppression without stem cell support. Current trials suggest that high dose immune suppressive therapy with or without autologous hematopoietic stem cell support can induce remission of previously refractory disease. Follow-up is too brief to determine if intense immune suppression, and more specifically autologous HSCT, will ultimately cure SLE. It is conceivable that an allogeneic source of stem cells from a normal donor (e.g. HLA matched sibling) will be required to achieve a cure. It is also possible that autologous HSCT, even if not curative, may prolong the life of patients with otherwise high-risk features. In carefully selected patients, the potential benefits of this procedure may outweigh the risks. Plenum Publishing Corporation, 2000 Immune suppression nationallicence systemic lupus nationallicence hematopoietic stem cell transplantation nationallicence Burt Richard The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut Marmont Alberto The Department of Hematology, Ospedale San Martino, Genova, Italy aut Schroeder James The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut Rosa Robert The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut Traynor Ann The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 31-37 0271-9142 20:1<31 2000 20 10875 https://doi.org/10.1023/A:1006638510160 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006638510160 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burt Richard The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Marmont Alberto The Department of Hematology, Ospedale San Martino, Genova, Italy aut NATIONALLICENCE 700 1- Schroeder James The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Rosa Robert The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Traynor Ann The Robert H. Lurie Cancer Center, Northwestern University Medical Center, Chicago, Illinois, USA aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 31-37 0271-9142 20:1<31 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer