caa a22 4500 475748050 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006690526998 doi (NATIONALLICENCE)springer-10.1023/A:1006690526998 Nash Richard Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D1-100, 98109-1024, Seattle, Washington aut Prospects of Stem Cell Transplantation in Autoimmune Diseases [Elektronische Daten] [Richard Nash] Severe autoimmune diseases are not cured by current conventional treatments. Preclinical studies of treatments requiring stem cell transplantation have shown sustained remissions in some models of autoimmune diseases. Both autologous stem cell transplantation after high-dose immunoablative therapy and allogeneic stem cell transplantation have a profound effect on the recipient's immunological system. Pilot clinical studies of autologous stem cell transplantation are being conducted. Sustained remissions will require the induction of tolerance to autoantigens during recovery. In a group of patients highly selected to minimize transplant-related mortality, allogeneic stem cell transplantation should be tested to determine if elimination of the autoreactive immunological system will achieve sustained remissions. These are promising therapies which will require long-term follow-up of patients to evaluate efficacy. Plenum Publishing Corporation, 2000 Bone marrow transplantation nationallicence autoimmune diseases nationallicence multiple sclerosis nationallicence systemic sclerosis nationallicence systemic lupus erythematosis nationallicence Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 38-45 0271-9142 20:1<38 2000 20 10875 https://doi.org/10.1023/A:1006690526998 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006690526998 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nash Richard Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D1-100, 98109-1024, Seattle, Washington aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 38-45 0271-9142 20:1<38 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer