caa a22 4500 475748069 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1006634309251 doi (NATIONALLICENCE)springer-10.1023/A:1006634309251 Does Hemopoietic Stem Cell Transplantation Have a Role in Treatment of Severe Rheumatoid Arthritis? [Elektronische Daten] [Raymond Lowenthal, Stewart Graham] Based on animal models and limited clinical experience, there is considerable interest in use of high-dose immunosuppression followed by hemopoietic stem cell transplantation as treatment for severe rheumatoid arthritis. Because of its relatively low treatment-related mortality and morbidity, autologous transplantation is a more attractive option than allogeneic transplantation for initial clinical trials, even though anecdotal reports suggest that allogeneic transplantation has a greater likelihood of bringing about long-term disease control. The approach remains experimental with many unanswered questions such as the value and safety of high-dose therapy without transplantation, the need for T cell purging, the possible deleterious effects of post-transplant hemopoietic growth factors and the potential of "mini” allogeneic transplantation (a process whereby intense immunosuppression is combined with less intense myelosuppression). To achieve quick progress it is essential that clinical trials be carefully designed with all cases being reported to the Autoimmune Disease Stem Cell Project Database. Plenum Publishing Corporation, 2000 Rheumatoid arthritis nationallicence bone marrow transplantation nationallicence G-CSF nationallicence peripheral blood stem cells nationallicence Lowenthal Raymond Departments of Haematology/Oncology, Royal Hobart Hospital, GPO Box 10611, 7001, Hobart, Tasmania, Australia aut Graham Stewart Departments of Haematology/Oncology, Royal Hobart Hospital, GPO Box 10611, 7001, Hobart, Tasmania, Australia aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 17-23 0271-9142 20:1<17 2000 20 10875 https://doi.org/10.1023/A:1006634309251 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006634309251 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lowenthal Raymond Departments of Haematology/Oncology, Royal Hobart Hospital, GPO Box 10611, 7001, Hobart, Tasmania, Australia aut NATIONALLICENCE 700 1- Graham Stewart Departments of Haematology/Oncology, Royal Hobart Hospital, GPO Box 10611, 7001, Hobart, Tasmania, Australia aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/1(2000-01-01), 17-23 0271-9142 20:1<17 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer