caa a22 4500 475748093 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1026468001834 doi (NATIONALLICENCE)springer-10.1023/A:1026468001834 Soluble β2-μ-Associated and β2-μ-Free HLA Class I Heavy Chain Serum Levels in Interferon-α Nonresponder Chronic Hepatitis C Patients. Markers of Immune Activation, and Response to Antiviral Retreatment [Elektronische Daten] [Francesco Puppo, Francesco Torre, Paola Contini, Massimo Ghio, Sabrina Brenci, Renata Brizzolara, Nicoletta Sinelli, Nadia Campo, Francesco Indiveri, Antonino Picciotto] The serum levels of soluble β2-μ-associated and β2-μ-free HLA class I heavy chains were determined in 28 interferon-α nonresponder chronic hepatitis C patients retreated with interferon-α plus ribavirin and in 70 healthy subjects. The baseline levels of β2-μ-associated and β2-μ-free HLA class I heavy chains were significantly higher in patients than in healthy controls(P = 0.001). The levels of β2-μ-associated HLA class I heavy chains significantly increased in responder patients with respect to nonresponders at the third month of treatment(P = 0.03). At the sixth month of treatment and after 6 months of follow up the levels of β2-μ-associated HLA class I heavy chains decreased in responder patients and increased in nonresponders. The levels of β2-μ-free HLA class I heavy chains showed only minor changes during and after treatment. We suggest that the determination of hepatitis C virus RNA levels combined with soluble β2-μ-associated HLA class I heavy chains, as a marker of immune activation, could identify interferon-α non responder chronic hepatitis C patients most likely to respond to a retreatment with interferon-α plus ribavirin. Plenum Publishing Corporation, 2000 Chronic hepatitis C nationallicence soluble HLA nationallicence interferon-α nationallicence ribavirin nationallicence hepatitis C virus RNA nationallicence Puppo Francesco Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Torre Francesco Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Contini Paola Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Ghio Massimo Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Brenci Sabrina Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Brizzolara Renata Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Sinelli Nicoletta Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Campo Nadia Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Indiveri Francesco Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Picciotto Antonino Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/6(2000-11-01), 486-490 0271-9142 20:6<486 2000 20 10875 https://doi.org/10.1023/A:1026468001834 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026468001834 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Puppo Francesco Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Torre Francesco Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Contini Paola Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Ghio Massimo Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Brenci Sabrina Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Brizzolara Renata Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Sinelli Nicoletta Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Campo Nadia Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Indiveri Francesco Clinical Immunology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Picciotto Antonino Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/6(2000-11-01), 486-490 0271-9142 20:6<486 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer