caa a22 4500 47574814X CHVBK 20180406123519.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1026459800016 doi (NATIONALLICENCE)springer-10.1023/A:1026459800016 Elevation of Transforming Growth Factor-β1 Is Associated with Recurrent Miscarriage [Elektronische Daten] [Mayumi Ogasawara, Koji Aoki, Tomomi Aoyama, Kinue Katano, Yoshiro Iinuma, Yasuhiko Ozaki, Kaoru Suzumori] To investigate the significance of transforming growth factor-β1 (TGF-β1) in reproduction we have compared plasma levels in normal pregnant women and patients suffering miscarriages. We examined 188 normal pregnant women and 12 pregnant women with miscarriages. Eight women with severe recurrent miscarriages (mean ± SD of previous number of miscarriages; 10.4 ± 2.4 times) were also examined before conception; 34 nonpregnant women served as controls. Plasma TGF-β1 level increased with the gestational week and returned within the normal range 1 month after delivery. The levels among pregnant women with miscarriages (mean ± SD; 2.44 ± 0.83 ng/ml) were significantly higher than those of pregnant controls (1.74 ± 0.95 ng/ml) of matched gestational weeks; levels among nonpregnant women with severe recurrent miscarriages were extremely elevated (4.1 ± 3.04 ng/ml) compared to the control value (1.34 ± 0.59 ng/ml). These data suggest that TGF-β1 may be necessary to maintain pregnancy but also may be a risk factor for recurrent miscarriages. Plenum Publishing Corporation, 2000 Transforming growth factor β1 nationallicence pregnancy nationallicence miscarriage nationallicence recurrent miscarriage nationallicence Ogasawara Mayumi Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Aoki Koji Department of Obstetrics and Gynecology, Nagoya City Johsai Hospital, 453, Nagoya, Japan aut Aoyama Tomomi Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Katano Kinue Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Iinuma Yoshiro Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Ozaki Yasuhiko Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Suzumori Kaoru Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/6(2000-11-01), 453-457 0271-9142 20:6<453 2000 20 10875 https://doi.org/10.1023/A:1026459800016 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026459800016 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ogasawara Mayumi Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 700 1- Aoki Koji Department of Obstetrics and Gynecology, Nagoya City Johsai Hospital, 453, Nagoya, Japan aut NATIONALLICENCE 700 1- Aoyama Tomomi Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 700 1- Katano Kinue Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 700 1- Iinuma Yoshiro Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 700 1- Ozaki Yasuhiko Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 700 1- Suzumori Kaoru Department of Obstetrics and Gynecology, Nagoya City University Medical School, 4678601, Nagoya, Japan aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/6(2000-11-01), 453-457 0271-9142 20:6<453 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer