caa a22 4500 475748247 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1006629328178 doi (NATIONALLICENCE)springer-10.1023/A:1006629328178 Molecular Events of Bacterial-Induced Maturation ofDendritic Cells [Elektronische Daten] [Maria Rescigno, Francesca Granucci, Paola Ricciardi-Castagnoli] In order to protect the body from infectious microorganisms, mammals have developed powerful lines of defense, consisting in innate and adaptive immune responses. The innate response is phylogenetically more ancient and, for a long time, it has been considered to be broadly directed to microorganisms. However, the discovery of a new class of receptors, involved in recognition of patterns characteristic of groups of microorganisms (the toll-like receptor family) has re-evaluated the role of the innate immune system as a discriminating system. Indeed, there is increasing evidence that the induction of different types of effector adaptive responses are directed by the innate immune system after recognition of particular groups of pathogens. The central role of Dendritic cells (DC) in the induction of adaptive immune responses towards infectious agents has been extensively described, but, recently, a new role of DC as a link between the non-antigen- and the antigen-specific responses has been proposed. DC have, indeed, the capacity to recruit and activate cells of the innate immune system upon inflammation. Thus, understanding the interaction of bacteria with DC, and the early molecular events resulting from this interaction may shed some light on the mechanisms of initiation of the immune response to infectious agents and on aspects of invasiveness, pathogenicity, and the persistence of certain bacteria. Plenum Publishing Corporation, 2000 Dendritic cells nationallicence bacteria nationallicence toll-like receptors nationallicence NF-kB nationallicence LPS nationallicence antigen presentation nationallicence Rescigno Maria Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut Granucci Francesca Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut Ricciardi-Castagnoli Paola Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 161-166 0271-9142 20:3<161 2000 20 10875 https://doi.org/10.1023/A:1006629328178 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006629328178 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rescigno Maria Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut NATIONALLICENCE 700 1- Granucci Francesca Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut NATIONALLICENCE 700 1- Ricciardi-Castagnoli Paola Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 161-166 0271-9142 20:3<161 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer