caa a22 4500 475748255 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1006645731813 doi (NATIONALLICENCE)springer-10.1023/A:1006645731813 Antioxidative Capacity in Patients with CommonVariable Immunodeficiency [Elektronische Daten] [J. Reichenbach, R. Schubert, C. Schwan, K. M¨uller, H. B¨ohles, S. Zielen] Highly reactive oxygen species (ROS) are involved in T-cell activation and in the defense against environmental pathogens. An imbalance of ROS generation, detoxifying scavenger enzymes, and molecules with antioxidant capacity could contribute to the increased susceptibility to cancer and infections in severe humoral immunodeficiency. We studied antioxidant status, i.e., plasma antioxidant capacity (TEAC), retinol, α-tocopherol, ubiquinol, and the number of activated T cells in 16 patients with common variable immunodeficiency (CVID) compared to age-matched healthy controls. As expected, patients showed significantly increased levels of activated HLA-DR and CD45RO-expressing T cells. Plasma levels of the endogenous ROS scavenger ubiquinol (Q 10) were significantly lower in patients as compared to controls. However, patients showed only slightly reduced levels of TEAC as well as the exogenous antioxidants retinol and α-tocopherol. Although no correlation of the number of activated T cells and antioxidant capacity could be demonstrated, an increase in ROS and a diminished reactive oxygen scavenger capacity may be involved in the disease process in patients with common variable immunodeficiency. Plenum Publishing Corporation, 2000 Oxidative stress nationallicence CVID nationallicence TEAC nationallicence vitamins nationallicence ubiquinol nationallicence Reichenbach J. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut Schubert R. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut Schwan C. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut M¨uller K. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut B¨ohles H. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut Zielen S. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 221-226 0271-9142 20:3<221 2000 20 10875 https://doi.org/10.1023/A:1006645731813 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006645731813 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reichenbach J. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut NATIONALLICENCE 700 1- Schubert R. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut NATIONALLICENCE 700 1- Schwan C. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut NATIONALLICENCE 700 1- M¨uller K. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut NATIONALLICENCE 700 1- B¨ohles H. Department of Pediatrics, Johann Wolfgang Goethe Universit¨at, Frankfurt, Germany aut NATIONALLICENCE 700 1- Zielen S. Department of Pediatrics, Rheinische Friedrich-Wilhelms Universit¨at, Bonn, Germany aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 221-226 0271-9142 20:3<221 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer