caa a22 4500 475748263 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1006641630904 doi (NATIONALLICENCE)springer-10.1023/A:1006641630904 Elevation of IL-18 in Human Sepsis [Elektronische Daten] [Stephen Grobmyer, Edward Lin, Stephen Lowry, David Rivadeneira, Strite Potter, Philip Barie, Carl Nathan] Interleukin-18 (IL-18) is a recently identified immunoregulatory cytokine that shares biochemical features with IL-1β and acts in part by inducing interferon-gamma (IFN-γ). Endotoxic bacterial lipopolysaccharide (LPS) (1 or 2 ng/kg) was insufficient to increase plasma IL-18 in five healthy adults measured 3, 12, and 24 hr following challenge. In contrast, in the first 96 hr of admission to the surgical intensive care unit, mean maximal serum IL-18 was elevated (1122 ± 259 pg/ml) in nine septic patients compared to six healthy adults (191 ± 42 pg/ml), P < 0.01). Serum IL-18 concentrations in septic patients did not correlate with other measured inflammatory mediators: tumor necrosis factor, IL-6, IL-10, or secretory leukocyte protease inhibitor. Therefore, IL-18 circulates in healthy adults and is a component of the human systemic inflammatory response. Further, stimuli other than LPS may induce IL-18 production in vivo in human sepsis. Plenum Publishing Corporation, 2000 IL-18 nationallicence sepsis nationallicence human nationallicence endotoxemia nationallicence cytokines nationallicence Grobmyer Stephen Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut Lin Edward Department of Surgery, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, 08903, New Brunswick, New Jersey aut Lowry Stephen Department of Surgery, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, 08903, New Brunswick, New Jersey aut Rivadeneira David Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut Potter Strite Department of Microbiology and Immunology, Weill Medical College of Cornell University, 10021, New York, New York aut Barie Philip Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut Nathan Carl Department of Microbiology and Immunology, Weill Medical College of Cornell University, 10021, New York, New York aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 212-215 0271-9142 20:3<212 2000 20 10875 https://doi.org/10.1023/A:1006641630904 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006641630904 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grobmyer Stephen Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut NATIONALLICENCE 700 1- Lin Edward Department of Surgery, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, 08903, New Brunswick, New Jersey aut NATIONALLICENCE 700 1- Lowry Stephen Department of Surgery, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, 08903, New Brunswick, New Jersey aut NATIONALLICENCE 700 1- Rivadeneira David Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut NATIONALLICENCE 700 1- Potter Strite Department of Microbiology and Immunology, Weill Medical College of Cornell University, 10021, New York, New York aut NATIONALLICENCE 700 1- Barie Philip Department of Surgery, Weill Medical College of Cornell University, 10021, New York, New York aut NATIONALLICENCE 700 1- Nathan Carl Department of Microbiology and Immunology, Weill Medical College of Cornell University, 10021, New York, New York aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 212-215 0271-9142 20:3<212 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer