caa a22 4500 475748301 CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1006633429087 doi (NATIONALLICENCE)springer-10.1023/A:1006633429087 Human Immunodeficiency Virus Type 1 Replication,Immune Activation, and Circulating CytotoxicT Cells Against Uninfected CD4+ T Cells [Elektronische Daten] [Shyamasundaran Kottilil, Jane Gamberg, Ian Bowmer, Julia Trahey, Constance Howley, Maureen Gallant, Michael Grant] Cytotoxic T lymphocytes (CTL) that kill uninfected activated CD4+ T cells can be induced in vitro by stimulating CD8+ T cells with activated autologous CD4+ T cells. Similar CTL have been detected in circulating T cells from human immunodeficiency virus type 1 (HIV)-infected individuals. To define the in vivo correlates of this CTL activity, we studied plasma β-2 microglobulin and HIV RNA levels, T-lymphocyte subset counts, and expression of CD28 on CD8+ T cells concurrently with circulating CTL activity against uninfected CD4+ T cells in 75 HIV-infected individuals at different stages of disease progression. Mean values of each parameter were compared in subsets of this group of 75 segregated on the basis of this CTL activity. The group with CTL against uninfected activated CD4+ T lymphocytes had more CD8+ T cells, a higher percentage of CD28− CD8+ T cells, and higher plasma levels of HIV RNA and β-2 microglobulin. CTL against uninfected activated CD4+ T cells were predominantly CD28− and in HIV-infected individuals were associated with immunological or virological evidence of progressive disease. In HIV infection, circulating CTL activity against uninfected activated CD4+ T lymphocytes is associated with immune activation, CD8+ T cell expansion, accumulation of CD28− CD8+ T cells, and inadequate suppression of HIV replication. Plenum Publishing Corporation, 2000 HIV nationallicence cytotoxic T lymphocytes nationallicence CD4, CD8, CD28− T cells nationallicence immune activation nationallicence Kottilil Shyamasundaran Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut Gamberg Jane Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut Bowmer Ian Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut Trahey Julia Health Care Corporation of St. John's, A1B 3V6, St. John's, Newfoundland, Canada aut Howley Constance Health Care Corporation of St. John's, A1B 3V6, St. John's, Newfoundland, Canada aut Gallant Maureen Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut Grant Michael Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 175-186 0271-9142 20:3<175 2000 20 10875 https://doi.org/10.1023/A:1006633429087 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006633429087 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kottilil Shyamasundaran Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Gamberg Jane Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Bowmer Ian Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Trahey Julia Health Care Corporation of St. John's, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Howley Constance Health Care Corporation of St. John's, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Gallant Maureen Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 700 1- Grant Michael Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, A1B 3V6, St. John's, Newfoundland, Canada aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 175-186 0271-9142 20:3<175 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer