caa a22 4500 47574831X CHVBK 20180406123519.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1006659211340 doi (NATIONALLICENCE)springer-10.1023/A:1006659211340 Chemokines and Dendritic Cell Traffic [Elektronische Daten] [Silvano Sozzani, Paola Allavena, Annunciata Vecchi, Alberto Mantovani] Localization in tissues and migration to lymphoid organs are essential steps in the immunobiology of dendritic cells (DC). Chemokines play an important role in guiding the traffic of DC. Receptor expression and responsiveness to constitutively made chemokines account for the presence of DC in normal tissues. Inflammatory chemokines and nonchemokine attractants promote recruitment and localization of DC at sites of inflammation and infection. Upon exposure to maturation signals, DC undergo a chemokine receptor switch, with down-regulation of inflammatory chemokine receptors followed by induction of CCR7. These temporally coordinated events allow DC to leave tissues and to localize in lymphoid organs by responding to CCR7 agonists. DC are also present in tumors that produce chemokines, but their significance remains to be defined. In addition to responding to chemokines, DC are a major source of certain chemokines such as macrophage-derived chemokine. The interaction of DC with chemokines is essential to the function of these cells in normal and pathological conditions and may provide tools for novel therapeutic strategies. Plenum Publishing Corporation, 2000 Chemotaxis nationallicence receptors nationallicence tumors nationallicence leukocytes nationallicence Sozzani Silvano Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut Allavena Paola Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut Vecchi Annunciata Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut Mantovani Alberto Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 151-160 0271-9142 20:3<151 2000 20 10875 https://doi.org/10.1023/A:1006659211340 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006659211340 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sozzani Silvano Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut NATIONALLICENCE 700 1- Allavena Paola Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut NATIONALLICENCE 700 1- Vecchi Annunciata Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut NATIONALLICENCE 700 1- Mantovani Alberto Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/3(2000-05-01), 151-160 0271-9142 20:3<151 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer