caa a22 4500 475748360 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1006611518223 doi (NATIONALLICENCE)springer-10.1023/A:1006611518223 Thymic Involution in Aging [Elektronische Daten] [Richard Aspinall, Deborah Andrew] The size of the na¨ıve T-cell pool is governed by output from the thymus and not by replication. This pool contributes cells to the activated/memory T-cell pool whose size can be increased through cell multiplication; both pools together constitute the peripheral T-cell pool. Aging is associated with involution of the thymus leading to a reduction in its contribution to the na¨ıve T-cell pool; however, despite this diminished thymic output, there is no significant decline in the total number of T cells in the peripheral T-cell pool. There are, however, considerable shifts in the ratios of both pools of cells, with an increase in the number of activated/memory T cells and the accumulation in older individuals of cells that fail to respond to stimuli as efficiently as T cells from younger individuals. Aging is also associated with a greater susceptibility to some infections and some cancers. An understanding of the causal mechanism of thymic involution could lead to the design of a rational therapy to reverse the loss of thymic tissue, renew thymic function, increase thymic output, and potentially improve immune function in aged individuals. Plenum Publishing Corporation, 2000 Thymus nationallicence atrophy nationallicence aging nationallicence involution nationallicence transgenic mice nationallicence IL-7 nationallicence Aspinall Richard Department of Immunology, ICSTM at Chelsea and Westminster Hospital, SW10 9N, London, England aut Andrew Deborah Department of Immunology, ICSTM at Chelsea and Westminster Hospital, SW10 9N, London, England aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 250-256 0271-9142 20:4<250 2000 20 10875 https://doi.org/10.1023/A:1006611518223 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006611518223 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aspinall Richard Department of Immunology, ICSTM at Chelsea and Westminster Hospital, SW10 9N, London, England aut NATIONALLICENCE 700 1- Andrew Deborah Department of Immunology, ICSTM at Chelsea and Westminster Hospital, SW10 9N, London, England aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 250-256 0271-9142 20:4<250 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer