caa a22 4500 475748395 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1006619820040 doi (NATIONALLICENCE)springer-10.1023/A:1006619820040 Humoral Immunity Against Glutamic Acid Decarboxylase and Tyrosine Phosphatase IA-2 in Lambert-Eaton Myasthenic Syndrome [Elektronische Daten] [Laurence Hermitte, Nicole Martin-Moutot, Jose Boucraut, Roselyne Barone, Catherine Atlan-Gepner, Micha¨el Seagar, Jean Pouget, Jean-Pierre Kleisbauer, Fran¸cois Couraud, Bernard Vialettes] Some β-cell-specific autoantigens also are present in the central nervous system. Furthermore, stiff man syndrome, an autoimmune neurological disease, is frequently associated with diabetes and shares with this one an anti-GAD and IA-2 humoral immunoreactivity. We wondered whether these autoantibodies could be found in other neurological diseases with a present or supposed autoimmune origin. So, anti-GAD65 (GAD65A) and anti-IA-2 (IA-2A) autoantibodies were assayed in various neurological diseases. There was a higher prevalence of such antibodies in Lambert-Eaton myasthenic syndrome (LEMS) (GAD65A, 35%; IA-2A, 21%; double positivity, 18%) compared to amyotrophic lateral sclerosis (18%, 12%, and 12%, respectively) and multiple sclerosis (10%, 3%, and 3%, respectively). In LEMS, the humoral reaction was more frequent and/or appeared earlier in the paraneoplastic forms. The detection of such autoantibodies in patients with small-cell lung carcinoma (SCLC) without LEMS suggests that these autoantigens, GAD65 and IA-2, could be produced by SCLC tissue. Plenum Publishing Corporation, 2000 Lambert-Eaton myasthenic syndrome nationallicence small-cell lung carcinoma nationallicence glutamic acid decarboxylase nationallicence IA-2 tyrosine phosphatase nationallicence Hermitte Laurence Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut Martin-Moutot Nicole Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut Boucraut Jose Laboratoire d'Immunologie, JE 2056, Universit´e de la M´editerran´ee, 13385, Marseille Cedex 05, France aut Barone Roselyne Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut Atlan-Gepner Catherine Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut Seagar Micha¨el Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut Pouget Jean Service de Neurologie et Maladies Neuromusculaires, H^opital d'adulte de la Timone, 264 rue St Pierre, 13385, Marseille Cedex 05, France aut Kleisbauer Jean-Pierre Service des Maladies respiratoires, H^opital Sainte Marguerite, 270 Bd Ste Marguerite, 13274, Marseille Cedex 09, France aut Couraud Fran¸cois Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut Vialettes Bernard Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 287-293 0271-9142 20:4<287 2000 20 10875 https://doi.org/10.1023/A:1006619820040 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006619820040 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hermitte Laurence Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 700 1- Martin-Moutot Nicole Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut NATIONALLICENCE 700 1- Boucraut Jose Laboratoire d'Immunologie, JE 2056, Universit´e de la M´editerran´ee, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 700 1- Barone Roselyne Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 700 1- Atlan-Gepner Catherine Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 700 1- Seagar Micha¨el Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut NATIONALLICENCE 700 1- Pouget Jean Service de Neurologie et Maladies Neuromusculaires, H^opital d'adulte de la Timone, 264 rue St Pierre, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 700 1- Kleisbauer Jean-Pierre Service des Maladies respiratoires, H^opital Sainte Marguerite, 270 Bd Ste Marguerite, 13274, Marseille Cedex 09, France aut NATIONALLICENCE 700 1- Couraud Fran¸cois Laboratoire de Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Facult´e de M´edecine Secteur Nord, Bd Pierre Dramard, 13323, Marseille Cedex 15, France aut NATIONALLICENCE 700 1- Vialettes Bernard Laboratoire de Diab´etologie, UPRES-EA 2193, IFR 35, Universit´e de la M´editerran´ee, Bd Jean Moulin, 13385, Marseille Cedex 05, France aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 287-293 0271-9142 20:4<287 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer