caa a22 4500 475748409 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1017223602293 doi (NATIONALLICENCE)springer-10.1023/A:1017223602293 The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse [Elektronische Daten] [Weng Nan-PIng, Richard Hodes] The molecular regulation of telomere length has been well elucidated by a series of elegant studies over the past decade. More recently, experimental evidence has accrued that addresses the challenging question of if and how telomere length regulation may contribute to normal human aging or to human disease. Recent studies in mice have provided a mammalian precedent indicating that telomerase deficiency can lead to in vivo dysfunction, most probably as a consequence of progressive telomere shortening. In humans, the evidence that telomere shortening might lead to in vivo dysfunction is far less direct, although the recent description of telomerase deficiency and telomere shortening associated with the DKC syndrome is suggestive of such a link. Methodologies exist and continue to be developed that are increasingly capable of manipulating telomerase activity and telomere length in human cells. It remains to be determined whether scientifically rigorous and (equally important) medically ethical approaches will emerge to directly assess the ability of telomere length modulation to correct functional disorders of human cellular function ex vivo or, more challenging still, in vivo. Plenum Publishing Corporation, 2000 Nan-PIng Weng aut Hodes Richard aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 257-267 0271-9142 20:4<257 2000 20 10875 https://doi.org/10.1023/A:1017223602293 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1017223602293 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nan-PIng Weng aut NATIONALLICENCE 700 1- Hodes Richard aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 257-267 0271-9142 20:4<257 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer