caa a22 4500 475748425 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1006659401385 doi (NATIONALLICENCE)springer-10.1023/A:1006659401385 The Effect of Age on the B-Cell Repertoire [Elektronische Daten] [Marc Weksler, Paul Szabo] The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in part, by the decreased diversification of B cells in the germinal center where affinity maturation and isotype switching takes place. B cell number is strictly regulated and despite the decreased output of B cells by the bone marrow does not decline during aging. Self-renewal of peripheral B cells is sufficient to assure the stability of peripheral B cell number. However, when B cell production is stressed as, for example, following drug-induced lymphopenia, the rate of recovery of B cell number as well as of B cell diversity is compromised in old compared to young mice. Finally, aging is associated with the appearance of B cell clonal expansions which not only limit the diversity of the B cell repertoire but very likely give rise to monoclonal serum immunoglobulins and B cell neoplasms. Plenum Publishing Corporation, 2000 Aging nationallicence B cells nationallicence B cell repertoire nationallicence clonal B cell expansions nationallicence Weksler Marc Weill Medical College, Cornell University, 1300 York Avenue, 10021, New York, New York aut Szabo Paul Weill Medical College, Cornell University, 1300 York Avenue, 10021, New York, New York aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 240-249 0271-9142 20:4<240 2000 20 10875 https://doi.org/10.1023/A:1006659401385 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006659401385 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weksler Marc Weill Medical College, Cornell University, 1300 York Avenue, 10021, New York, New York aut NATIONALLICENCE 700 1- Szabo Paul Weill Medical College, Cornell University, 1300 York Avenue, 10021, New York, New York aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/4(2000-07-01), 240-249 0271-9142 20:4<240 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer