caa a22 4500 475748476 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1023/A:1006668013276 doi (NATIONALLICENCE)springer-10.1023/A:1006668013276 Expression of Perforin and Fas Ligand mRNA in the Liver of Viral Hepatitis [Elektronische Daten] [Masafumi Tagashira, Kazuhide Yamamoto, Kozo Fujio, Takuya Nagano, Ryoichi Okamoto, Naofumi Ibuki, Kazuhisa Yabushita, Shuji Matsumura, Nobuaki Okano, Takao Tsuji] Cytotoxic T lymphocytes (CTLs) play an important role in the pathogenesis of viral hepatitis. We studied the expression of mRNAs of perforin and Fas ligand (Fas-L) in biopsy specimens from chronic hepatitis B (CHB) (15 cases) and hepatitis C (CHC) patients (13 cases). Both perforin and Fas-L mRNAs were detected in all cases of both CHB and CHC. No messages were detected in the control livers from two cases of fatty liver, a case of Gilbert's syndrome, and a case of Dubin-Johnson syndrome. Semiquantitative analysis revealed a positive correlation between the intensity of perforin and Fas-L mRNAs in both CHB and CHC. In CHB, the intensity of both perforin and Fas-L mRNAs showed a positive correlation with the histological activity and serum alanine aminotransferase level, while the correlation was not apparent in CHC. These results suggest that both perforin and Fas/Fas-L systems are involved in the pathogenesis of liver cell injury of CHB and CHC. Plenum Publishing Corporation, 2000 Chronic hepatitis nationallicence cytotoxic T lymphocyte nationallicence polymerase chain reaction nationallicence perforin nationallicence Fas ligand nationallicence Tagashira Masafumi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Yamamoto Kazuhide First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Fujio Kozo First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Nagano Takuya First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Okamoto Ryoichi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Ibuki Naofumi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Yabushita Kazuhisa First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Matsumura Shuji First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Okano Nobuaki First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Tsuji Takao First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/5(2000-09-01), 347-353 0271-9142 20:5<347 2000 20 10875 https://doi.org/10.1023/A:1006668013276 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006668013276 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tagashira Masafumi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Yamamoto Kazuhide First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Fujio Kozo First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Nagano Takuya First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Okamoto Ryoichi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Ibuki Naofumi First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Yabushita Kazuhisa First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Matsumura Shuji First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Okano Nobuaki First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 700 1- Tsuji Takao First Department of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/5(2000-09-01), 347-353 0271-9142 20:5<347 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer