caa a22 4500 475748492 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1023/A:1006625412367 doi (NATIONALLICENCE)springer-10.1023/A:1006625412367 Gene Therapy in Experimental Autoimmune Encephalomyelitis [Elektronische Daten] [Peter Mathisen, Vincent Tuohy] Gene therapy traditionally has been associated with "gene replacement,” where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then introduced back into the patient as a way to correct an inherited genetic defect. However, several novel gene therapy strategies for treating autoimmune diseases recently have emerged. Strategies involving the use of several types of DNA vaccines, the application of various viral vectors, and the use of diverse cellular vectors have shown promise in inhibiting autoimmune-mediated inflammation and repairing tissue damaged as a result of autoimmune attack. In the current review, we examine and discuss the development and proposed use of emerging gene therapy strategies for the treatment of autoimmune disease with specific emphasis on experimental autoimmune encephalomyelitis (EAE), an animal model widely used in multiple sclerosis (MS) research. Plenum Publishing Corporation, 2000 EAE/MS nationallicence stem cells nationallicence CNS nationallicence T-cells nationallicence PLP nationallicence Mathisen Peter Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio aut Tuohy Vincent Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/5(2000-09-01), 327-333 0271-9142 20:5<327 2000 20 10875 https://doi.org/10.1023/A:1006625412367 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006625412367 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mathisen Peter Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio aut NATIONALLICENCE 700 1- Tuohy Vincent Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/5(2000-09-01), 327-333 0271-9142 20:5<327 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer