caa a22 4500 475748603 CHVBK 20180406123520.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1006634530672 doi (NATIONALLICENCE)springer-10.1023/A:1006634530672 Elevated Plasma Levels of 90K (Mac-2 BP) Immunostimulatory Glycoprotein in HIV-1-Infected Children [Elektronische Daten] [B. Gr¨oschel, J. Braner, M. Funk, R. Linde, H. Doerr, J. Cinatl Jr., S. Iacobelli] 90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 μg/ml) were higher than in HIV-1 uninfected control group (6.3 μg/ml; P < 0.05). 90K levels of HIV-1-infected children classified as stage B and C (median, 15.0 μg/ml and 22.7 μg/ml, respectively) were higher compared to children with stage A disease (median, 7.0 μg/ml; P < 0.05). A positive correlation (r = 0.5; P < 0.05) was found between 90K levels and HIV-1 RNA levels in 137 plasma samples of 18 HIV-1-infected children collected during a period of 1 year. No correlation was found between 90K levels and CD4 cell counts. These results suggest that 90K plasma levels may represent a novel marker of disease progression in HIV-1-infected children. Plenum Publishing Corporation, 2000 Human immunodeficiency virus type 1 (HIV-1) nationallicence 90K (Mac-2BP) nationallicence viral load nationallicence progression markers nationallicence immune system activation nationallicence Gr¨oschel B. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut Braner J. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut Funk M. Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt/M., Germany aut Linde R. Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt/M., Germany aut Doerr H. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut Cinatl Jr. J. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut Iacobelli S. Department of Oncology and Neurosciences, University G. D'Annunzio, Chieti, Italy aut Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/2(2000-03-01), 117-122 0271-9142 20:2<117 2000 20 10875 https://doi.org/10.1023/A:1006634530672 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006634530672 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gr¨oschel B. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Braner J. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Funk M. Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Linde R. Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Doerr H. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Cinatl Jr J. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany aut NATIONALLICENCE 700 1- Iacobelli S. Department of Oncology and Neurosciences, University G. D'Annunzio, Chieti, Italy aut NATIONALLICENCE 773 0- Journal of Clinical Immunology Kluwer Academic Publishers-Plenum Publishers 20/2(2000-03-01), 117-122 0271-9142 20:2<117 2000 20 10875 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer