caa a22 4500 475751965 CHVBK 20180406123526.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00010042 doi (NATIONALLICENCE)springer-10.1007/PL00010042 Ishida Tomomi Department of Surgery II, Mie University School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan, JP aut Immunohistochemical Expression of the CD44 Variant 6 in Colorectal Adenocarcinoma [Elektronische Daten] [Tomomi Ishida] The CD44 variant 6 (CD44 v6) has been postulated to be involved in both carcinogenesis and tumor progression. In the present study, CD44 v6 was stained immunohistochemically in 63 colorectal cancer tissues to assess significance of CD44 v6 in the carcinogenesis and progression of colorectal carcinoma. None of the normal colonocytes showed an expression of CD44 v6. CD44 v6 expression was very strong in 24, moderate in 13, and negative in 26 tumor tissues. A negative or moderate expression of CD44 v6 was significantly associated with a larger tumor size (P < 0.05) and invasion through the bowel wall (P < 0.01). There was no correlation between the expression of CD44 v6 and gross type, histologic differentiation, lymph node involvement, liver metastasis, and clinical stage of the disease. The present study showed that the expression of CD44 v6 was characteristic of neoplastic changes in the colonocytes and that a diminished expression of CD44 v6 was associated with the penetration of colorectal cancer through the bowel wall, but not with either lymph node or distant metastasis.: Springer-Verlag Tokyo, 2000 Key Words: CD44 variant 6, colorectal carcinoma, immunohistochemistry nationallicence https://doi.org/10.1007/PL00010042 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00010042 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ishida Tomomi Department of Surgery II, Mie University School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer