caa a22 4500 475751973 CHVBK 20180406123526.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00010044 doi (NATIONALLICENCE)springer-10.1007/PL00010044 The Relationship Between the Angiographic Findings and the Clinical Features of Carotid Artery Plaque [Elektronische Daten] [Dong-Ik Kim, Sun-Joung Lee, Byung-Boong Lee, Yong-il Kim, Chin-Sang Chung, Dae-Won Seo, Kwang-Ho Lee, Young-Hyeh Ko, Duk-Kyung Kim, Young-Soo Do, Hong-Sik Byun] The purpose of this study was to investigate the histological characteristics of atheromatous carotid plaque, and to analyze the relationship between the angiographic findings and the clinical features. We retrospectively reviewed 55 cases of carotid endarterectomy for extracranial internal carotid artery stenosis, who were treated at our institute from January 1995 to December 1997. The histological examination included hematoxylin-eosin staining, Masson-trichrome staining, and immunostaining for antismooth muscle antibody and anti-CD68 antibody. The main compositions of the carotid plaque included synthetic type vascular smooth muscle cells and extracellular matrix. The histological findings showed ulceration in 49 (89.1%) cases, calcium deposits in 42 (76.4%) cases, and an inflammatory reaction in 44 (80.0%) cases. Neurological abnormalities were strongly associated with plaque ulceration (P = 0.045) and an inflammatory reaction (P = 0.013), whereas no correlation existed regarding calcium deposits (P = 0.173). The angiographic findings showed ulceration in 46 (83.6%) cases. Plaque ulceration in the angiography findings showed no statistically significant correlation with the histologic findings (P = 0.410) and preoperative neurologic abnormalities (P = 0.059). All of the atherosclerotic risk factors such as hypertension, smoking, diabetes mellitus, hyperlipidemia, and myocardial infarction had no statistically significant correlation with the histological features of the carotid plaque. In conclusion, the main compositions of carotid plaque were synthetic-type vascular smooth muscle cells and extracellular matrix. The histological ulceration and inflammatory reaction of the plaque showed a statistically significant correlation with the preoperative neurologic symptoms, whereas no correlation was seen in the calcium deposits. Angiographic ulceration showed no correlation with the histological findings or preoperative neurologic abnormalities. In addition, the histological findings showed no correlation with the atherosclerotic risk factors.: Springer-Verlag Tokyo, 2000 Key Words: carotid, atherosclerosis, endarterectomy, stroke, pathology nationallicence Kim Dong-Ik Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Lee Sun-Joung Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Lee Byung-Boong Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Kim Yong-il Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Chung Chin-Sang Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Seo Dae-Won Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Lee Kwang-Ho Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Ko Young-Hyeh Department of Diagnostic Pathology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Kim Duk-Kyung Division of Cardiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Do Young-Soo Department of Radiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Byun Hong-Sik Department of Radiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut https://doi.org/10.1007/PL00010044 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00010044 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Dong-Ik Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Lee Sun-Joung Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Lee Byung-Boong Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Kim Yong-il Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Chung Chin-Sang Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Seo Dae-Won Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Lee Kwang-Ho Department of Neurology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Ko Young-Hyeh Department of Diagnostic Pathology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Kim Duk-Kyung Division of Cardiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Do Young-Soo Department of Radiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut NATIONALLICENCE 700 1- Byun Hong-Sik Department of Radiology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, 50 IL Won Dong, Kangnam-Ku, Seoul 135-710, Korea, KP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer