caa a22 4500 475752066 CHVBK 20180406123526.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00010040 doi (NATIONALLICENCE)springer-10.1007/PL00010040 Preoperative Intranasal Mupirocin Ointment Significantly Reduces Postoperative Infection with Staphylococcus aureus in Patients Undergoing Upper Gastrointestinal Surgery [Elektronische Daten] [Masahiko Yano, Yuichiro Doki, Masatoshi Inoue, Toshimasa Tsujinaka, Hitoshi Shiozaki, Morito Monden] Nasal carriage of Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) is associated with an increased risk for postoperative staphylococcal infection. This study was conducted to investigate the effect of preoperative nasal mupirocin treatment on the postoperative infections in patients undergoing upper gastrointestinal surgery. The intervention group consisted of 141 consecutive patients who underwent upper gastrointestinal surgery between March 1, 1997, and February 28, 1998. The patients in the intervention group were treated with intranasal mupirocin three times a day for 3 consecutive days before surgery. The incidence of postoperative staphylococcal infections in the intervention group was then compared with that of the historical control group. The control group consisted of 128 consecutive patients who underwent upper gastrointestinal surgery without mupirocin treatment between January 1, 1996 and December 31, 1996. The postoperative staphylococcal infection rate in the control group (11.7%) was significantly higher (P < 0.001) than in the intervention group (0.71%). The postoperative MRSA infection rate was significantly reduced by the intervention (control group 7.0% and intervention group 0%; P < 0.01). These results suggest that preoperative nasal eradication of S. aureus with mupirocin thus appears to be an effective measure to prevent postoperative staphylococcal infection in patients undergoing upper gastrointestinal surgery.: Springer-Verlag Tokyo, 2000 Key Words: staphylococcal infection, methicillin-resistant Staphylococcus aureus, mupirocin, nasal carriage, postoperative infection nationallicence Yano Masahiko Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Doki Yuichiro Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Inoue Masatoshi Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Tsujinaka Toshimasa Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Shiozaki Hitoshi Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Monden Morito Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut https://doi.org/10.1007/PL00010040 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00010040 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yano Masahiko Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut NATIONALLICENCE 700 1- Doki Yuichiro Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut NATIONALLICENCE 700 1- Inoue Masatoshi Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut NATIONALLICENCE 700 1- Tsujinaka Toshimasa Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut NATIONALLICENCE 700 1- Shiozaki Hitoshi Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut NATIONALLICENCE 700 1- Monden Morito Department of Surgery II, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer