caa a22 4500 475752112 CHVBK 20180406123527.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00010047 doi (NATIONALLICENCE)springer-10.1007/PL00010047 The Facilitation of Peritoneal Dissemination of a Tumor by Laparotomy in a Rabbit Model [Elektronische Daten] [Nobuo Murata, Hideyuki Ishida, Tomohisa Nomura, Hirofumi Yamada, Yasuo Idezuki] The effects of conventional laparotomy and laparoscopic surgery on the peritoneal dissemination of VX2 tumors were evaluated in a rabbit model. Either 5 × 103 or 5 × 104 of VX2 tumor cells were inoculated into the peritoneal cavities of rabbits which were divided into three groups according to the procedure performed, namely, a conventional laparotomy group (group 1), a laparoscopy group (group 2), and a control group (group 3). All the animals were killed 2 weeks after the treatment to examine the spread of the VX2 tumor in the omentum. In the experiment in which 5 × 103 tumor cells were inoculated, no significant difference was found in the number of metastases among the three groups. Conversely, after inoculating 5 × 104 tumor cells, the mean numbers of metastatic colonies greater than 1 mm in diameter in the greater omentum were 14.4 ± 4.7 in group 1, 9.9 ± 2.4 in group 2, and 3.3 ± 1.1 in group 3, with a significant difference between groups 1 and 3, and between groups 2 and 3, but not between groups 1 and 2. In conclusion, conventional laparotomy facilitated the greatest peritoneal dissemination of a VX2 tumor in this animal model when 5 × 104 tumor cells were inoculated. Furthermore, laparoscopic surgery influences tumor growth to almost the same degree as conventional laparotomy.: Springer-Verlag Tokyo, 2000 Key Words: laparoscopic surgery, operative surgery, carcinoma, peritoneal neoplasm, surgical stress nationallicence Murata Nobuo Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut Ishida Hideyuki Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut Nomura Tomohisa Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut Yamada Hirofumi Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut Idezuki Yasuo Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut https://doi.org/10.1007/PL00010047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00010047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murata Nobuo Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Ishida Hideyuki Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Nomura Tomohisa Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Yamada Hirofumi Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Idezuki Yasuo Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer