caa a22 4500 475752244 CHVBK 20180406123527.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s005950070118 doi (NATIONALLICENCE)springer-10.1007/s005950070118 Identification of high-risk breast cancer patients from genetic changes of their tumors [Elektronische Daten] [Masahiro Watatani, Hiroki Inui, Koichi Nagayama, Yukihito Imanishi, Keisuke Nishimura, Yukihiko Hashimoto, Eiju Yamauchi, Toshiya Hojo, Yoshikazu Kotsuma, Munehisa Yamato, Nobuteru Matsunami, Masayuki Yasutomi] To identify the genetic prognostic markers for breast cancer, we analyzed loss of heterozygosity (LOH) at 11p, 16q, 17p, 17q, and 18q, as well as amplification of theERBB2, INT2, andMYC genes, in 131 patients with breast carcinoma, 49 of whom had lymph node involvement, but none of whom had distant metastases. Among the several chromosome arms tested, LOH at 17q was correlated with lymph node metastasis. Amplification of theERBB2, MYC, andINT2 genes was found more frequently in tumors from patients with lymph node metastases than in tumors from those without lymph node metastases. Univariate analysis demonstrated that LOH at 17q andINT2 amplification were factors influencing disease-free survival (DFS). A multivariate analysis was performed on 89 tumors that were able to be evaluated for both LOH at 17q andINT2 amplification, and the results showed that patients who had tumors with these genetic changes were more likely to have a poor prognosis. The findings of this study suggest that investigating genetic changes, in addition to conventional clinicopathologic factors, may contribute to defining groups of breast cancer patients with differences in prognosis. Springer-Verlag, 2000 genetic changes nationallicence prognostic factor nationallicence breast cancer nationallicence amplification nationallicence loss of heterozygosity nationallicence Watatani Masahiro First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Inui Hiroki First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Nagayama Koichi First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Imanishi Yukihito First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Nishimura Keisuke First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Hashimoto Yukihiko First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Yamauchi Eiju First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Hojo Toshiya First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Kotsuma Yoshikazu Kotsuma Clinic, 1-11-45 Uemachi, 598-0007, Izumisano, Japan aut Yamato Munehisa First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Matsunami Nobuteru First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Yasutomi Masayuki First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut Surgery Today Springer-Verlag 30/6(2000-06-01), 516-522 0941-1291 30:6<516 2000 30 595 https://doi.org/10.1007/s005950070118 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070118 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watatani Masahiro First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Inui Hiroki First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Nagayama Koichi First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Imanishi Yukihito First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Nishimura Keisuke First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Hashimoto Yukihiko First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Yamauchi Eiju First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Hojo Toshiya First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Kotsuma Yoshikazu Kotsuma Clinic, 1-11-45 Uemachi, 598-0007, Izumisano, Japan aut NATIONALLICENCE 700 1- Yamato Munehisa First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Matsunami Nobuteru First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 700 1- Yasutomi Masayuki First Department of Surgery, Kinki University School of Medicine, 377-2 Oonohigashi, 589-8511, Osakasayama, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/6(2000-06-01), 516-522 0941-1291 30:6<516 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer