caa a22 4500 475752392 CHVBK 20180406123528.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s005950070058 doi (NATIONALLICENCE)springer-10.1007/s005950070058 Increased Fibrinolytic Activity and Body Cavity Coagula [Elektronische Daten] [Yutaka Yamamoto, Gou Wakabayashi, Nobutoshi Ando, Naoki Aikawa, Masaki Kitajima] When a large volume of coagulum remains in the body cavity after trauma or surgery, secondary fibrinolysis occurs, which disturbs the hemostatic balance and results in rebleeding. To better understand this condition, we conducted a clinical study on patients with and without coagula and an experimental study on fibrinolytic activity in a rat model. The results of the clinical study showed that when coagula existed in the body cavity, the blood levels of the fibrin degradation products D-dimer and fibrinopeptide Bβ15-42 remained high compared with when subjects were under similar stress but without the presence of coagula. In the experimental studies, fibrinolytic activity of the omentum, measured by the fibrin plate method, was higher in rats with hemoperitoneum. This suggests that increased fibrinolytic activity may lead to rebleeding from the area of transient hemostasis when coagulum is present in the body cavity. Springer-Verlag, 2000 Key Words Body cavity coagula nationallicence Rebleeding nationallicence Fibrinolytic activity nationallicence Yamamoto Yutaka Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut Wakabayashi Gou Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut Ando Nobutoshi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut Aikawa Naoki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut Kitajima Masaki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut https://doi.org/10.1007/s005950070058 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070058 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamamoto Yutaka Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut NATIONALLICENCE 700 1- Wakabayashi Gou Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut NATIONALLICENCE 700 1- Ando Nobutoshi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut NATIONALLICENCE 700 1- Aikawa Naoki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut NATIONALLICENCE 700 1- Kitajima Masaki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan<, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer