caa a22 4500 475752481 CHVBK 20180406123528.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s005950070067 doi (NATIONALLICENCE)springer-10.1007/s005950070067 Undifferentiated Spindle-Cell Sarcoma of the Chest Wall with Vascular Endothelial Growth Factor Expression: Report of a Case [Elektronische Daten] [Akira Iyoda, Kenzo Hiroshima, Toshikazu Yusa, Yoshiaki Tsukamoto, Tetsuya Toyozaki, Takehiko Fujisawa, Hidemi Ohwada] The expressions of some growth factors have been immunohistochemically confirmed in several kinds of tumors, and in particular the expression of vascular endothelial growth factor (VEGF) has been reported to be closely related to tumor cell proliferation. We report herein a case of undifferentiated spindle-cell sarcoma arising in the chest wall with VEGF expression. A 67-year-old man, who presented with coughing, was found to have an abnormal shadow on his right chest wall. He was admitted to Chiba Rosai Hospital and preoperative diagnosis of the tumor was sarcoma. The tumor was thus resected along with the right chest wall and right lower lobe of the lung. Histopathologically, the tumor cells were spindle-shaped and showed severe atypism. The tumor cells were positive for vimentin and VEGF antibody with immunohistochemical staining, but they did not show differentiation to any special type of sarcoma. The tumor was diagnosed to be undifferentiated spindle-cell sarcoma. The microvessel density of the tumor was measured using CD34 and it was found to be higher than the average density of usual sarcomas. The prognosis of this case was poor. The patient died of tumor metastasis to the lung and bone 1 year later in spite of the fact that the tumor was resected. Springer-Verlag, 2000 Key Words Spindle cell sarcoma nationallicence Chest wall nationallicence Vascular endothelial growth factor nationallicence Iyoda Akira Division of Pathology and aut Hiroshima Kenzo Division of Pathology and aut Yusa Toshikazu Department of Respiratory Surgery, Chiba Rosai Hospital, Chiba, Japan, JP aut Tsukamoto Yoshiaki Division of Pathology and aut Toyozaki Tetsuya Division of Pathology and aut Fujisawa Takehiko Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan, JP aut Ohwada Hidemi Division of Pathology and aut https://doi.org/10.1007/s005950070067 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070067 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iyoda Akira Division of Pathology and aut NATIONALLICENCE 700 1- Hiroshima Kenzo Division of Pathology and aut NATIONALLICENCE 700 1- Yusa Toshikazu Department of Respiratory Surgery, Chiba Rosai Hospital, Chiba, Japan, JP aut NATIONALLICENCE 700 1- Tsukamoto Yoshiaki Division of Pathology and aut NATIONALLICENCE 700 1- Toyozaki Tetsuya Division of Pathology and aut NATIONALLICENCE 700 1- Fujisawa Takehiko Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan, JP aut NATIONALLICENCE 700 1- Ohwada Hidemi Division of Pathology and aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer