caa a22 4500 475752570 CHVBK 20180406123528.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s005950070096 doi (NATIONALLICENCE)springer-10.1007/s005950070096 Pathomorphological and histological prognostic factors in curatively resected ductal adenocarcinoma of the pancreas [Elektronische Daten] [Willibald Meyer, Christian Jurowich, Markus Reichel, Bernhard Steinhäuser, Peter Wünsch, Christoph Gebhardt] The fate of patients with potentially resectable carcinomas is not only determined by the pTNM tumor stage, but also possibly by tumor-biological factors. The aim of this study was to identify these prognostic factors in patients undergoing primary curative (R0) resection. The study retrospectively analyzed 113 patients with ductal adenocarcinoma who were operated on between 1986 and 1995. R0 resection was able to be performed in 93 patients. Lymph node metastases were found in 73%. The rates of lymph vessel and perineural invasion were 83.5% and 45%, respectively. Among the 25 carcinomas without lymph node metastases, 64% already had lymph vessel invasion and 48% had perineural invasion. The cumulative 5-year survival rate of the 91 surviving patients analyzed was 10.5%. Depending on the tumor stage we found a significant difference in 5-year survival rates between patients without lymph node metastases (26.5%) and those with lymph node involvement (5%) (P 5 0.008). A multivariate analysis only identified lymph vessel invasion (L0/1), tumor size (≦/≦2 cm), and tumor grading (G) to have significant and independent prognostic value. Lymph vessel invasion, tumor size, and tumor grading proved to be independent factors determining long-term prognosis. Springer-Verlag, 2000 Ductal pancreatic carcinoma nationallicence Curative resection nationallicence Prognostic factors nationallicence Meyer Willibald Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Jurowich Christian Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Reichel Markus Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Steinhäuser Bernhard Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Wünsch Peter Department of Institute of Pathology, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Gebhardt Christoph Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut Surgery Today Springer-Verlag 30/7(2000-07-01), 582-587 0941-1291 30:7<582 2000 30 595 https://doi.org/10.1007/s005950070096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meyer Willibald Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 700 1- Jurowich Christian Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 700 1- Reichel Markus Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 700 1- Steinhäuser Bernhard Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 700 1- Wünsch Peter Department of Institute of Pathology, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 700 1- Gebhardt Christoph Department of Abdominal, Thoracic and Endocrine Surgery, Klinikum Nürnberg-Nord, Prof. Ernst-Nathan-Strasse 1, D-90419, Nürnberg, Germany aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/7(2000-07-01), 582-587 0941-1291 30:7<582 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer