caa a22 4500 475752619 CHVBK 20180406123528.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s005950070100 doi (NATIONALLICENCE)springer-10.1007/s005950070100 Experimental study of an artificial esophagus using a collagen sponge, a latissimus dorsi muscle flap, and split-thickness skin [Elektronische Daten] [Motoko Saito, Takashi Sakamoto, Masao Fujimaki, Kazuhiro Tsukada, Takashi Honda, Motohiro Nozaki] The time and effort spent trying to devise an artificial esophagus have not yet resulted in success, and leakage and strictures at the anastomotic sites remain the most frequent complications. We developed an artificial esophagus with a bilayered structure made of porous collagen sponge (artificial dermis; AD), a latissimus dorsi muscle flap (LD), and split-thickness skin (STS). We investigated whether the use of AD prevented the contraction of grafted skin and its effects on the extensibility of the neoesophagus in rabbits. We experimented with two groups. In the AD group, AD was applied to the surface of the LD. Three weeks later, the STS was grafted. In the control group, the STS was grafted directly onto the LD. The sizes of the STS in both groups 3 weeks after the graft were, respectively, 56.6% ± 4.1% and 39.0% ± 10.2% of the initial surface area of the STS (P < 0.01). The roll made in the AD group had better extensibility than that in the control group. We replaced the cervical esophagus in 12 rabbits with the neoesophagus made from AD, STS, and LD. The longest survival period was 16 days. Esophagography did not reveal either anastomotic leakage or stenosis in any of the five rabbits in the experiments. These findings suggested that AD can thus be used to create a more suitable hybrid artificial esophagus. Springer-Verlag, 2000 Artificial esophagus nationallicence Collagen sponge nationallicence Artificial dermis nationallicence Split-thickness skin nationallicence Saito Motoko Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut Sakamoto Takashi Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut Fujimaki Masao Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut Tsukada Kazuhiro Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut Honda Takashi Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical College, Tokyo, Japan aut Nozaki Motohiro Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical College, Tokyo, Japan aut Surgery Today Springer-Verlag 30/7(2000-07-01), 606-613 0941-1291 30:7<606 2000 30 595 https://doi.org/10.1007/s005950070100 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saito Motoko Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut NATIONALLICENCE 700 1- Sakamoto Takashi Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut NATIONALLICENCE 700 1- Fujimaki Masao Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut NATIONALLICENCE 700 1- Tsukada Kazuhiro Second Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyma, Japan aut NATIONALLICENCE 700 1- Honda Takashi Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical College, Tokyo, Japan aut NATIONALLICENCE 700 1- Nozaki Motohiro Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical College, Tokyo, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/7(2000-07-01), 606-613 0941-1291 30:7<606 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer