caa a22 4500 475752724 CHVBK 20180406123529.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s005950070002 doi (NATIONALLICENCE)springer-10.1007/s005950070002 The Prognosis of Patients with Non-Small Cell Lung Cancer Found to Have Carcinomatous Pleuritis at Thoracotomy [Elektronische Daten] [Yukito Ichinose, Ryosuke Tsuchiya, Teruaki Koike, Osamu Kuwahara, Ken Nakagawa, Yasushi Yamato, Koichi Kobayashi, Yoh Watanabe, Masahiro Kase, Kohei Yokoi] Non-small cell lung cancer with carcinoma-tous pleuritis is considered to be a contraindication of surgical resection. The objective of this study was to clarify the prognosis of patients with non-small cell lung cancer in whom carcinomatous pleuritis was found at thoracotomy. A questionnaire survey on the survival of patients with carcinomatous pleuritis found at thoracotomy between January 1985 and December 1994 was conducted by the Japan Clinical Oncology Group. According to the data collected from 21 hospitals, 8 813 patients with non-small cell lung cancer underwent thoracotomy, 284 (3.2%) of whom were found to have carcinomatous pleuritis. Information on survival was available for 227 of these patients, 34 (15%) of whom underwent thoracotomy alone without resection, whereas 193 (85%) underwent surgical resection. Of the 193 resected patients, 155 had no macroscopical residual tumor apart from the carcinomatous pleuritis. The 5-year survival rate was 14%. According to a univariate analysis, female sex, the presence of adenocarcinoma, a tumor size of less than 3.0 cm, no clinical lymph node metastasis, and no macroscopical residual tumor had a significantly favorable impact on survival. A multivariate analysis revealed that the extent of clinical lymph node metastasis (P = 0.006), histology (P = 0.028), and the absence or presence of a macroscopic residual tumor after the operation (P = 0.045) were predominant prognostic factors. The 5-year survival rate of 83 patients with three positive variables was 24%. The prognosis of patients with adenocarcinoma found to have carcinomatous pleuritis at thoracotomy was not necessarily unfavorable if there was no clinically detected lymph node metastasis and no residual tumor apart from the carcinomatous pleuritis. Springer-Verlag, 2000 Key words Non-small cell lung cancer nationallicence Carcinomatous pleuritis nationallicence Surgical resection nationallicence Ichinose Yukito Department of Chest Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan, JP aut Tsuchiya Ryosuke National Cancer Center Hospital, Tokyo, Japan, JP aut Koike Teruaki Niigata Cancer Center Hospital, Niigata, Japan, JP aut Kuwahara Osamu Toneyama National Hospital, Osaka, Japan, JP aut Nakagawa Ken Cancer Institute, Tokyo, Japan, JP aut Yamato Yasushi Niigata University School of Medicine, Niigata, Japan, JP aut Kobayashi Koichi Keio University, Tokyo, Japan, JP aut Watanabe Yoh Kanazawa University School of Medicine, Ishikawa, Japan, JP aut Kase Masahiro Yokohama Municipal Citizen's Hospital, Kanagawa, Japan, JP aut Yokoi Kohei Tochigi Cancer Center, Tochigi, Japan, JP aut https://doi.org/10.1007/s005950070002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ichinose Yukito Department of Chest Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan, JP aut NATIONALLICENCE 700 1- Tsuchiya Ryosuke National Cancer Center Hospital, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Koike Teruaki Niigata Cancer Center Hospital, Niigata, Japan, JP aut NATIONALLICENCE 700 1- Kuwahara Osamu Toneyama National Hospital, Osaka, Japan, JP aut NATIONALLICENCE 700 1- Nakagawa Ken Cancer Institute, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Yamato Yasushi Niigata University School of Medicine, Niigata, Japan, JP aut NATIONALLICENCE 700 1- Kobayashi Koichi Keio University, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Watanabe Yoh Kanazawa University School of Medicine, Ishikawa, Japan, JP aut NATIONALLICENCE 700 1- Kase Masahiro Yokohama Municipal Citizen's Hospital, Kanagawa, Japan, JP aut NATIONALLICENCE 700 1- Yokoi Kohei Tochigi Cancer Center, Tochigi, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer