caa a22 4500 475752864 CHVBK 20180406123529.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050050 doi (NATIONALLICENCE)springer-10.1007/s005950050050 The effects of intraoperative glucose infusion on portal blood insulin concentration and hepatic mitochondrial redox state during surgery: Comparison of short-term and continuous infusions [Elektronische Daten] [Jun Hayakawa, Hisahiko Motohashi, Motonori Sairenji, Osamu Kobayashi, Makoto Takahashi, Yutaka Usuda] The relationships between the blood glucose level, portal blood immunoreactive insulin (IRI) concentration, ketogenesis, and hepatic mitochondrial redox state associated with intraoperative glucose administration were evaluated in patients undergoing total gastrectomy. A total of 26 patients were randomly allocated to two groups according to the type of infusion given; group 1 was given a short-term glucose infusion of 25 g in 30 min and group 2 was given a continuous glucose infusion of 10 g/h. The blood glucose concentration peaked 30min after the goucose infusion was commenced, then decreased in group 1, despite a continuous rise in group 2. A temporary but significantly higher blood glucose level was observed in group 1 than in group 2, 30 and 60 min after the infusion was commenced. The portal blood IRI concentrations and arterial ketone body ratio (AKBR) continued to increase and the blood ketone body concentrations continued to decline after the start of the glucose infusion in both groups; however, after 60 and 120min, the portal blood IRI and AKBR levels were significantly higher, and the blood ketone body levels significantly lower in group 1 than in group 2. These findings suggest that intraoperative glucose administration is beneficial for insulin secretion, ketogenesis, and the hepatic mitochondrial redox state, and that short-term infusion is superior to continuous infusion. Springer-Verlag, 2000 arterial ketone body ratio nationallicence blood glucose concentration nationallicence blood ketone body concentration nationallicence glucose infusion nationallicence portal blood insulin concentration nationallicence Hayakawa Jun Department of Anesthesia, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut Motohashi Hisahiko Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut Sairenji Motonori Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut Kobayashi Osamu Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut Takahashi Makoto Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut Usuda Yutaka Department of Anesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan aut Surgery Today Springer-Verlag 30/3(2000-03-01), 228-234 0941-1291 30:3<228 2000 30 595 https://doi.org/10.1007/s005950050050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayakawa Jun Department of Anesthesia, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Motohashi Hisahiko Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Sairenji Motonori Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Kobayashi Osamu Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Takahashi Makoto Department of Surgery Third Division, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Usuda Yutaka Department of Anesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/3(2000-03-01), 228-234 0941-1291 30:3<228 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer