caa a22 4500 475752880 CHVBK 20180406123529.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050061 doi (NATIONALLICENCE)springer-10.1007/s005950050061 Long-term survival of a poor-risk octogenarian following wedge resection under VATS for small-cell lung cancer: Report of a case [Elektronische Daten] [Shunsuke Kobayashi, Shinichiro Okada, Toru Hasumi, Nobuyuki Sato, Shigefumi Fujimura] We describe herein the case of an 81-year-old man who has remained disease-free for more than 3 years after undergoing a wedge resection of cStage I small-cell lung cancer (SCLC) under video-assisted thoracoscopic surgery (VATS), with no adjunct chemotherapy or radiotherapy. The patient had compromised pulmonary function and was a poor surgical risk. As he could not have endured a conventional lobectomy or intensive chemotherapy, a nonanatomical wedge resection of the area of lung involved by the primary tumor was carried out under VATS. Cancer cells from the resected tumor were cultured and the growth characteristics and sensitivity to 12 anticancer drugs were examined. The majority of primary cultured cells proliferated in a monolayer, like paving stones, resembling the growth pattern of nonsmall-cell carcinoma cells in vitro. The subcultured cells were resistant to most of the drugs, but showed weak sensitivity to cisplatin (CDDP), adriamycin (ADR), and vincristine (VCR). Therefore, the patient was discharged with no adjunct postoperative therapy and was followed up at an outpatient clinic. He has remained alive and disease-free for more than 3 years. Thus, we considered that performing wedge resection under VATS for a primary tumor could be appropriate treatment for selected patients with cStage I SCLC in a peripheral region, especially if they are elderly and a poor surgical risk. Springer-Verlag, 2000 small-cell lung cancer nationallicence wedge resection nationallicence video-assisted thoracoscopic surgery nationallicence octogenarian nationallicence long-term survival nationallicence Kobayashi Shunsuke Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut Okada Shinichiro Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut Hasumi Toru Department of Surgery, Sendai Kousei Hospital, 4-12 Hirosemachi, Aoba-ku, 980, Sendai, Japan aut Sato Nobuyuki Department of Surgery, Sendai Kousei Hospital, 4-12 Hirosemachi, Aoba-ku, 980, Sendai, Japan aut Fujimura Shigefumi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut Surgery Today Springer-Verlag 30/3(2000-03-01), 286-290 0941-1291 30:3<286 2000 30 595 https://doi.org/10.1007/s005950050061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi Shunsuke Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Okada Shinichiro Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Hasumi Toru Department of Surgery, Sendai Kousei Hospital, 4-12 Hirosemachi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Sato Nobuyuki Department of Surgery, Sendai Kousei Hospital, 4-12 Hirosemachi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Fujimura Shigefumi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/3(2000-03-01), 286-290 0941-1291 30:3<286 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer