caa a22 4500 475752902 CHVBK 20180406123529.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050054 doi (NATIONALLICENCE)springer-10.1007/s005950050054 Pathological Assessment of the Response of Locally Advanced Breast Cancer to Neoadjuvant Chemotherapy and Its Implications for Surgical Management [Elektronische Daten] [Monir El-Didi, Mohamed Moneer, Hussein Khaled, Soheir Makarem] The effectiveness of breast-conserving surgery for patients with locally advanced breast cancer (LABC) after neoadjuvant chemotherapy (NACT) is still a controversial issue, and variable incidences of locoregional failures have been reported. The present study was conducted to pathologically assess the response of LABC to NACT, and also to evaluate the efficacy of preoperative clinical examination and mammography in detecting these pathological changes. A total of 38 patients with LABC received NACT in the form of three cycles of fluorouracil/adriamycin/cyclophosphamide and were then subjected to a mastectomy. The residual tumors in the mastectomy specimens were measured, mapped, and compared to the pretreatment and preoperative clinical and mammographic findings for evaluation. An objective response to NACT was observed in 70.4% of the patients; however, only 26.7% of them were suitable candidates for conservative surgery. The rest of the responders showed an increased incidence of multifocality and in situ lesions localized within the original tumor-bearing area. Both clinical examinations and mammography were inadequate for the selection of candidates for breast conservation. Tumor regression by NACT is probably induced by a process of tumor segmentation. It is also associated with an increased incidence of multifocality and in situ lesions. Springer-Verlag, 2000 locally advanced breast cancer nationallicence neoadjuvant chemotherapy nationallicence tumor multifocality nationallicence El-Didi Monir Department of Pathology, National Cancer Institute, Cairo, Egypt aut Moneer Mohamed Department of Surgery, Mataria Teaching Hospital, 35 EI-Galaa St., Ramsis Square, Cairo, Egypt aut Khaled Hussein Medical Oncology, National Cancer Institute, Cairo, Egypt aut Makarem Soheir Diagnostic Radiology, Mataria Teaching Hospital, 35 EI-Galaa St., Ramsis Square, Cairo, Egypt aut Surgery Today Springer-Verlag 30/3(2000-03-01), 249-254 0941-1291 30:3<249 2000 30 595 https://doi.org/10.1007/s005950050054 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050054 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El-Didi Monir Department of Pathology, National Cancer Institute, Cairo, Egypt aut NATIONALLICENCE 700 1- Moneer Mohamed Department of Surgery, Mataria Teaching Hospital, 35 EI-Galaa St., Ramsis Square, Cairo, Egypt aut NATIONALLICENCE 700 1- Khaled Hussein Medical Oncology, National Cancer Institute, Cairo, Egypt aut NATIONALLICENCE 700 1- Makarem Soheir Diagnostic Radiology, Mataria Teaching Hospital, 35 EI-Galaa St., Ramsis Square, Cairo, Egypt aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/3(2000-03-01), 249-254 0941-1291 30:3<249 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer