caa a22 4500 47575297X CHVBK 20180406123529.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050053 doi (NATIONALLICENCE)springer-10.1007/s005950050053 The efficacy and side effects of gelatin-resorcinol formaldehyde-glutaraldehyde (GRFG) glue for preventing and sealing pulmonary air leakage [Elektronische Daten] [Hiroaki Nomori, Hirotoshi Horio, Keiichi Suemasu] This study was conducted to examine the efficacy and side effects of gelatin-resorcinol formaldehyde-glutaraldehyde (GRFG) glue, when used for preventing or sealing pulmonary air leakage during lung surgery. Formaldehyde-glutaraldehyde (FG) jelly was prepared by mixing FG fluid with 2.5% carboxymethyl cellulose to increase its viscosity. A GRFG glue-spreading stapler was employed to prevent air leakage from the staple line when cutting emphysematous lung tissue in 26 patients, 25 of whom underwent video-assisted thoracoscopic surgery (VATS) and 1, open thoracotomy. A glue-sealing procedure was employed to stop existing pulmonary air leakage in a further 36 patients, 28 of whom underwent VATS and 8, open thoracotomy. The glue-spreading stapler technique prevented air leakage in all 26 patients (100%), while the glue-sealing procedure for pulmonary air leakage stopped air leakage in 31 of the 36 patients (86%). Two patients who underwent glue sealing for air leakage from a deeply cut lung surface suffered massive pulmonary air leakage on postoperative day (POD) 1 and 6, respectively, and required repeat surgery to suture the lung fistula. A transient fever of 38°-39° developed on POD 7 in 6 of the 62 patients (9.7%), but no other complications were observed. These results demonstrated that GRFG is safe and effective in preventing or stopping pulmonary air leakage in the peripheral lung, but not for stopping air leakage from a deeply cut lung. Springer-Verlag, 2000 air leakage nationallicence lung fistula nationallicence glue nationallicence thoracoscopy nationallicence side effects nationallicence Nomori Hiroaki Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut Horio Hirotoshi Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut Suemasu Keiichi Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut Surgery Today Springer-Verlag 30/3(2000-03-01), 244-248 0941-1291 30:3<244 2000 30 595 https://doi.org/10.1007/s005950050053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nomori Hiroaki Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Horio Hirotoshi Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Suemasu Keiichi Department of Thoracic Surgery, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, 108-0073, Tokyo, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/3(2000-03-01), 244-248 0941-1291 30:3<244 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer