caa a22 4500 475753054 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s005950070037 doi (NATIONALLICENCE)springer-10.1007/s005950070037 Changes in T-cell receptor subsets after cardiac surgery in children [Elektronische Daten] [Toshiyuki Yamaguchi, Arata Murakami, Kazuaki Fukahara, Tetsuyuki Ueda, Fukiko Ichida, Toshio Miyawaki, Takuro Misaki] T cells are divided into two subsets, αβ and γδ, according to the T-cell receptor (TCR) expressed. Recent findings indicate that γδ T cells serve as the first defense against microbial pathogens, and represent a link between innate and acquired immunity. We conducted a study to investigate the changes in circulating TCR subsets after cardiac surgery in children. Blood samples from 24 children who underwent cardiac surgery with cardiopulmonary bypass (CPB) were collected serially to analyze TCR subsets by flow cytometry. The αβ T cells reached a nadir on postoperative day (POD) 1, but recovered to pre-CPB levels on POD 3. On the other hand, the γδ T cells decreased after CPB and did not recover to pre-CPB levels even after POD 7. The ααb/γδ T-cell ratio was increased after POD 3. In children, γδ T cells recover more slowly than αβ T cells after cardiac surgery. These changes in TCR subsets may contribute to postoperative immunosuppression. Springer-Verlag, 2000 γδ T Cell nationallicence Cardiac surgery nationallicence Yamaguchi Toshiyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Murakami Arata First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Fukahara Kazuaki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Ueda Tetsuyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Ichida Fukiko Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Miyawaki Toshio Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Misaki Takuro First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut Surgery Today Springer-Verlag 30/10(2000-10-01), 875-878 0941-1291 30:10<875 2000 30 595 https://doi.org/10.1007/s005950070037 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070037 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamaguchi Toshiyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Murakami Arata First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Fukahara Kazuaki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Ueda Tetsuyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Ichida Fukiko Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Miyawaki Toshio Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Misaki Takuro First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/10(2000-10-01), 875-878 0941-1291 30:10<875 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer