caa a22 4500 475753062 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s005950070043 doi (NATIONALLICENCE)springer-10.1007/s005950070043 The likely transformation of papillary thyroid carcinoma into anaplastic carcinoma during postoperative radioactive iodine-131 therapy: Report of a case [Elektronische Daten] [Kiyoshi Shingu, Shinya Kobayashi, Shiro Yokoyama, Minoru Fujimori, Kazuhiko Asanuma, Ken-ichi Ito, Yoshihisa Hama, Masayuki Maruyama, Ritsu Kusama, Jun Amano] We report herein a case of papillary carcinoma which appeared to transform into anaplastic carcinoma during postoperative radioactive iodine-131 (131I) therapy. A 67-year-old man who was diagnosed as having papillary thyroid carcinoma with bilateral neck lymph node involvement and multiple lung metastases underwent total thyroidectomy prior to131I therapy. Immediately after a second course of131I therapy, the patient complained of right neck pain and swelling, and a biopsy of the swollen neck lymph node was taken. Histologic examination of this biopsy specimen revealed anaplastic carcinoma. With p53 immunohistochemical staining, both the primary tumor and the biopsy specimen were positive. We speculate that first, some DNA damage in tumor cells was induced by the initial131I therapy, but neither DNA repair nor cell apoptosis occurred because the p53 gene was already mutated; then further DNA damage was induced by the second131I therapy, leading to anaplastic transformation. Springer-Verlag, 2000 Papillary thyroid carcinoma nationallicence Anaplastic carcinoma nationallicence 131I therapy nationallicence p53 nationallicence Shingu Kiyoshi Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Kobayashi Shinya Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Yokoyama Shiro Department of Surgery, Nagano Red Cross Hospital, 380-8582, Nagano, Japan aut Fujimori Minoru Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Asanuma Kazuhiko Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Ito Ken-ichi Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Hama Yoshihisa Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Maruyama Masayuki Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Kusama Ritsu Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Amano Jun Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Surgery Today Springer-Verlag 30/10(2000-10-01), 910-913 0941-1291 30:10<910 2000 30 595 https://doi.org/10.1007/s005950070043 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070043 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shingu Kiyoshi Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Kobayashi Shinya Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Yokoyama Shiro Department of Surgery, Nagano Red Cross Hospital, 380-8582, Nagano, Japan aut NATIONALLICENCE 700 1- Fujimori Minoru Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Asanuma Kazuhiko Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Ito Ken-ichi Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Hama Yoshihisa Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Maruyama Masayuki Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Kusama Ritsu Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Amano Jun Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/10(2000-10-01), 910-913 0941-1291 30:10<910 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer