caa a22 4500 475753127 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s005950070047 doi (NATIONALLICENCE)springer-10.1007/s005950070047 Development of an inveterate gastroduodenal ulcer caused by antral G-cell hyperplasia of the stomach (pseudo-Zollinger-Ellison Syndrome): Report of a case [Elektronische Daten] [Shinsuke Takeno, Tsuyoshi Noguchi, Nobuhiro Kubo, Tetsuro Sato, Yuzo Uchida, Akira Moriuchi] We describe herein the case of a 54-year-old Japanese woman in whom an inveterate peptic ulcer developed in association with pseudo-Zollinger-Ellison Syndrome (pseudo-ZES). The patient presented with weight loss and abdominal distension caused by antral and duodenal stenosis due to an inveterate peptic ulcer. Her serum gastrin level was very high; however, no evidence of a gastrinoma or carcinoid tumor was detected by preoperative examinations or surgery. A total gastrectomy and double-tract reconstruction was performed, and pathological examination revealed a gastric ulcer (UL-IV) with no histopathological evidence of a neoplasm. Immunohistochemical staining showed an obvious increase in the number of endocrine cells that were positive for chromogranin A, and marked G-cell hyperplasia was observed in the antral mucosa. Furthermore, the number of enterochromaffin-like cells was remarkably high. From the results of the immunohistochemical examination, the patient was diagnosed as having hypergastrinemia due to antral G-cell hyperplasia. Postoperatively, the patient's serum gastrin level fell rapidly to within the normal range, her nutritional status improved, and her weight increased by about 10 kg within 1 year. Springer-Verlag, 2000 Pseudo-Zollinger-Ellison syndrome nationallicence G-cell hyperplasia nationallicence Hypergastrinemia nationallicence Takeno Shinsuke Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut Noguchi Tsuyoshi Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut Kubo Nobuhiro Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut Sato Tetsuro Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut Uchida Yuzo Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut Moriuchi Akira Division of Pathology, Oita Almeida Hospital, 1315 Miyazaki, 870-1133, Oita, Japan aut Surgery Today Springer-Verlag 30/10(2000-10-01), 923-927 0941-1291 30:10<923 2000 30 595 https://doi.org/10.1007/s005950070047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeno Shinsuke Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Noguchi Tsuyoshi Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Kubo Nobuhiro Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Sato Tetsuro Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Uchida Yuzo Department of Surgery II, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Moriuchi Akira Division of Pathology, Oita Almeida Hospital, 1315 Miyazaki, 870-1133, Oita, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/10(2000-10-01), 923-927 0941-1291 30:10<923 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer