caa a22 4500 475753151 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s005950070036 doi (NATIONALLICENCE)springer-10.1007/s005950070036 A decreased serum concentration of nitrite/nitrate correlates with an increased plasma concentration of lactate during and after major surgery [Elektronische Daten] [Susumu Fujioka, Kiyoshi Mizumoto, Kazuo Okada] A decrease in the production of nitric oxide (NO) due to surgical stress has been reported. We investigated whether this decrease in NO production was related to cytokine induction and/or other clinical parameters. We therefore measured the concentrations of serum nitrite/nitrate (a stable end product of NO), serum interleukin (IL)-6, and standard clinical parameters in 13 patients undergoing major upper abdominal and thracoabdominal surgery at preanesthesia (PRE), 2h after a surgical incision (2H), at the end of surgery (END), and on the morning of postoperative days 1 (POD 1) and 3 (POD 3). The serum concentration of nitrite/nitrate was thus found to have significantly decreased at END, POD 1, and POD 3 compared with PRE. In addition, the serum nitrite/nitrate concentration correlated negatively with the plasma lactate level, and no relationship was observed between the serum nitrite/nitrate level and either the serum IL-6 level or any other clinical parameters. Our findings thus suggest that the decrease in the serum nitrite/nitrate level might therefore be related to tissue hypoperfusion both during and after major surgery. Springer-Verlag, 2000 Major surgery nationallicence Nitric oxide nationallicence Lactate nationallicence Fujioka Susumu Department of Anesthesia, Ageo Central General Hospital, 1-10-10 Kashiwaza, Ageo, 362-8588, Saitama, Japan aut Mizumoto Kiyoshi Department of Anesthesiology, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Okada Kazuo Department of Anesthesiology, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Surgery Today Springer-Verlag 30/10(2000-10-01), 871-874 0941-1291 30:10<871 2000 30 595 https://doi.org/10.1007/s005950070036 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070036 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujioka Susumu Department of Anesthesia, Ageo Central General Hospital, 1-10-10 Kashiwaza, Ageo, 362-8588, Saitama, Japan aut NATIONALLICENCE 700 1- Mizumoto Kiyoshi Department of Anesthesiology, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 700 1- Okada Kazuo Department of Anesthesiology, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/10(2000-10-01), 871-874 0941-1291 30:10<871 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer