caa a22 4500 475753216 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s005950070041 doi (NATIONALLICENCE)springer-10.1007/s005950070041 The effect of pentoxifylline on the healing of intestinal anastomosis in rats with experimental obstructive jaundice [Elektronische Daten] [Mustafa Cömert, Ferit Taneri, Ercüment Tekin, Emin Ersoy, Selçuk Öktemer, Erhan Onuk, Ersel Düzgün, Ferruh Ayoĝlu] The aims of this study were (1) to investigate the effect of experimental obstructive jaundice on the healing of intestinal anastomosis, and (2) to investigate the effect of pentoxifylline on the healing of intestinal anastomosis in rats with obstructive jaundice. Obstructive jaundice was induced in rats by the ligation and division of the common bile duct. Four days after this operation, either pentoxifylline or isotonic saline solution was administered intraperitoneally to these jaundiced rats and controls, and then intestinal anastomosis was performed. The concentrations of serum tumor necrosis factor α (TNF-α) and serum triglyceride of jaundiced and nonjaundiced rats were measured, and the quality of healing was evaluated by measuring the bursting preasure and hydroxyproline content of the anastomoses on the fifth and tenth days of anastomotic healing. Obstructive jaundice resulted in an impaired wound healing of the intestinal anastomosis in the rats. The administration of pentoxifylline to the jaundiced rats resulted in better anastomotic wound healing. The beneficial effects of pentoxifylline on anastomotic healing in rats with obstructive jaundice was attributed to its inhibitor effect on the endotoxin-induced TNF-α release from macrophages and monocytes, and the stabilizing effect on the neutrophils. Springer-Verlag, 2000 Pentoxifylline nationallicence Obstructive jaundice nationallicence Intestinal nationallicence anastomosis nationallicence Endotoxemia nationallicence Tumor necrosis nationallicence factor α nationallicence Cömert Mustafa Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Taneri Ferit Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Tekin Ercüment Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Ersoy Emin Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Öktemer Selçuk Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Onuk Erhan Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Düzgün Ersel Department of Biochemistry, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Ayoĝlu Ferruh Department of Public Health, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut Surgery Today Springer-Verlag 30/10(2000-10-01), 896-902 0941-1291 30:10<896 2000 30 595 https://doi.org/10.1007/s005950070041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cömert Mustafa Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Taneri Ferit Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Tekin Ercüment Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Ersoy Emin Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Öktemer Selçuk Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Onuk Erhan Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Düzgün Ersel Department of Biochemistry, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 700 1- Ayoĝlu Ferruh Department of Public Health, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/10(2000-10-01), 896-902 0941-1291 30:10<896 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer