caa a22 4500 475753305 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050594 doi (NATIONALLICENCE)springer-10.1007/s005950050594 Expression of CD44, Vascular Endothelial Growth Factor, and Proliferating Cell Nuclear Antigen in Severe Venous Invasional Colorectal Cancer and Its Relationship to Liver Metastasis [Elektronische Daten] [Yoshiaki Sumiyoshi, Yuichi Yamashita, Takafumi Maekawa, Norimi Sakai, Takayuki Shirakusa, Masahiro Kikuchi] The first step in liver metastasis is venous invasion by cancer cells from the primary tumor. However, even among cases where the histology shows extensive venous invasion by the primary tumor, we sometimes find cases without synchronous liver metastases. As a result, there is a strong possibility that, besides the established causes of colorectal cancer and that of cancer cells invading the veins, some other important causes for liver metastasis must exist. We investigated the expression rates of CD44, proliferating cell nuclear antigen (PCNA), and vascular endothelial growth factor (VEGF) in 28 primary colorectal tumors using immunohistological techniques, and examined an association with liver metastasis. Cases that are strongly positive for CD44 or PCNA have a higher rate of synchronous liver metastases than cases with either no expression or a low expression. We could find no correlation between the VEGF expression and synchronous liver metastasis. In cases with severe venous invasion, VEGF is not correlated with liver metastasis whereas CD44 and PCNA are correlated with liver metastasis. In cases where severe venous invasion is histologically observed, an immunohistochemical analysis for CD44 and PCNA should be done to assess the likelihood of liver metastases.: Springer-Verlag Tokyo, 2000 Key Words: CD44, vascular endothelial growth factor, proliferating cell nuclear antigen, liver metastasis, colorectal cancer nationallicence Sumiyoshi Yoshiaki Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Yamashita Yuichi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Maekawa Takafumi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Sakai Norimi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Shirakusa Takayuki Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Kikuchi Masahiro First Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut https://doi.org/10.1007/s005950050594 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050594 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sumiyoshi Yoshiaki Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut NATIONALLICENCE 700 1- Yamashita Yuichi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut NATIONALLICENCE 700 1- Maekawa Takafumi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut NATIONALLICENCE 700 1- Sakai Norimi Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut NATIONALLICENCE 700 1- Shirakusa Takayuki Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut NATIONALLICENCE 700 1- Kikuchi Masahiro First Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer