caa a22 4500 475753321 CHVBK 20180406123530.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050600 doi (NATIONALLICENCE)springer-10.1007/s005950050600 An Experimental Study of Atrial Natriuretic Peptide Levels and the Effect of Inhaled Nitric Oxide After Pneumonectomy [Elektronische Daten] [Shinzo Takamori, Hiroharu Mifune, Kohsuke Tayama, Masahiro Mitsuoka, Kohich Tamura, Yasuhiro Terasaki, Akihiro Hayashi, Kazuo Shirouzu] The aim of this study was to investigate the changes in atrial natriuretic peptide (ANP) levels and lung cyclic guanosine 3′,5′-monophosphate (cGMP) concentrations caused by pneumonectomy (Pn), and the effect of inhaled nitric oxide (NO) after Pn in a canine model. The mean pulmonary arterial pressure (PAP) and plasma ANP levels were measured over 180 min in two groups of dogs, one subjected to 60 min of 5 ppm NO inhalation (Pn + NO group, n = 5) and one subjected to 180 min without NO inhalation (Pn group, n = 5). The ANP and cGMP levels in the lung were also measured before and after Pn. Both the PAP and ANP levels increased significantly. Inhaled NO rapidly reduced the PAP and plasma ANP to levels similar to those before Pn. The lung ANP level was significantly increased after Pn, but inhaled NO reduced it to a level similar to that before Pn. The lung cGMP level, which was significantly decreased after Pn, was significantly increased by NO inhalation. These results indicate that NO administration may be effective for preventing post-Pn pulmonary hypertension, although an elevation in ANP does not reduce the PAP.: Springer-Verlag Tokyo, 2000 Key Words: pneumonectomy, pulmonary arterial pressure, nitric oxide, atrial natriuretic peptide, cyclic guanosine 3′,5′-monophosphate nationallicence Takamori Shinzo Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Mifune Hiroharu Institution of Animal Experiments, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Tayama Kohsuke Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Mitsuoka Masahiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Tamura Kohich Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Terasaki Yasuhiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Hayashi Akihiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Shirouzu Kazuo Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut https://doi.org/10.1007/s005950050600 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050600 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takamori Shinzo Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Mifune Hiroharu Institution of Animal Experiments, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Tayama Kohsuke Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Mitsuoka Masahiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Tamura Kohich Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Terasaki Yasuhiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Hayashi Akihiro Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut NATIONALLICENCE 700 1- Shirouzu Kazuo Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer