caa a22 4500 475753364 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050597 doi (NATIONALLICENCE)springer-10.1007/s005950050597 Current Techniques of Hyperthermic Isolated Limb Perfusion for Malignant Melanoma [Elektronische Daten] [Ryuji Tominaga, Hiroyuki Kohno, Hisanori Mayumi, Kimihiro Shiraishi, Shounosuke Nagae, Juichirou Nakayama, Hisataka Yasui] A retrospective study was conducted examining 25 patients with malignant melanoma who were treated by our new protocol for hyperthermic isolated limb perfusion. The characteristics of our techniques include: a lower priming volume of the extracorporeal circuit; a therapeutic temperature range of 40-41°C with 60 min hyperthermic perfusion; a nominal perfusion flow rate of 500 ml/min in the lower limb and 200 ml/min in the upper limb; and combined carboplatin with interferon-β as the adjuvant chemotherapy drug. In the lower extremity group, the arterial cannula size ranged from 8 to 14 F, while the venous cannula size ranged from 14 to 16 F. In the upper limb group, the arterial cannula size ranged from 6 to 8 F and the venous cannula size ranged from 10 to 12 F. No patient required any homologous blood transfusion postoperatively. No operative death or major complications occurred during the early postoperative period, confirming the safety of this treatment. Both optimal cannula size selection and maintaining perfusion temperature below 41°C were judged to be important in elimination of vascular and deep tissue injury.: Springer-Verlag Tokyo, 2000 Key Words: malignant melanoma, hyperthermic isolated perfusion, carboplatin, interferon-β nationallicence Tominaga Ryuji Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Kohno Hiroyuki Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Mayumi Hisanori Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Shiraishi Kimihiro Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Nagae Shounosuke Department of Dermatology, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Nakayama Juichirou Department of Dermatology, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Yasui Hisataka Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut https://doi.org/10.1007/s005950050597 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tominaga Ryuji Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Kohno Hiroyuki Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Mayumi Hisanori Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Shiraishi Kimihiro Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Nagae Shounosuke Department of Dermatology, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Nakayama Juichirou Department of Dermatology, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut NATIONALLICENCE 700 1- Yasui Hisataka Department of Cardiovascular Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-053, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer